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Cardiovascular autonomic neuropathy in type 2 diabetic patients

Ikaro Soares Santos Breder1, Andrei C Sposito2

  • 1Endocrinologist - Doctorate Student at the Laboratory of Vascular Biology and Atherosclerosis. -Faculty of medical Sciences (FCM) - State University of Campinas (Unicamp) - Campinas (SP) - Brasil.

Revista Da Associacao Medica Brasileira (1992)
|February 14, 2019
PubMed

Insights

Type 2 Diabetes Mellitus (T2DM) patients may develop cardiac autonomic neuropathy, increasing mortality. This review covers T2DM neuropathy concepts, diagnosis, and treatments, including new drugs with potential cardiac benefits.

Area of Science:

  • Endocrinology
  • Cardiology
  • Diabetology

Background:

  • Diabetes Mellitus is a prevalent chronic condition requiring multidisciplinary care.
  • Type 2 Diabetes Mellitus (T2DM) is associated with cardiac autonomic neuropathy (CAN).
  • CAN in T2DM significantly elevates mortality and morbidity risks.

Purpose of the Study:

  • To review current understanding of T2DM-related cardiac autonomic neuropathy.
  • To outline clinical features, diagnostic approaches, and prognostic factors.
  • To discuss potential therapeutic strategies for T2DM-induced CAN.

Main Methods:

  • Literature review of current concepts and research.
  • Analysis of clinical features and diagnostic criteria for CAN in T2DM.
  • Evaluation of treatment options, including novel pharmacotherapies.

Main Results:

  • CAN is a serious complication of T2DM, impacting cardiovascular health.
  • Early diagnosis and management are crucial for improving patient outcomes.
  • Emerging glucose-lowering agents show promise beyond glycemic control, potentially reducing cardiovascular events.

Conclusions:

  • Cardiac autonomic neuropathy is a critical concern in T2DM management.
  • A comprehensive approach involving various specialists is essential.
  • Novel pharmacological interventions may offer cardioprotective benefits in T2DM patients at risk.

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