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Related Experiment Videos

Treatment--metformin.

C J Bailey, M Nattrass

    Bailliere'S Clinical Endocrinology and Metabolism
    |May 1, 1988
    PubMed
    Summary
    This summary is machine-generated.

    Metformin improves insulin resistance in non-insulin-dependent diabetes mellitus (NIDDM) by enhancing insulin action at the cellular level, primarily post-receptor. This antihyperglycaemic agent effectively lowers blood glucose without causing hypoglycemia or weight gain.

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    Area of Science:

    • Endocrinology
    • Pharmacology
    • Metabolic Diseases

    Background:

    • Hyperglycemia in Non-Insulin-Dependent Diabetes Mellitus (NIDDM) is linked to insulin resistance.
    • Insulin resistance involves reduced insulin receptor binding and post-receptor defects.

    Purpose of the Study:

    • To evaluate Metformin's role in ameliorating insulin resistance in NIDDM.
    • To elucidate Metformin's mechanism of action on insulin target cells.

    Main Methods:

    • The study focuses on the pharmacological effects of Metformin.
    • Analysis of Metformin's impact on insulin receptor binding and post-receptor insulin action.

    Main Results:

    • Metformin enhances insulin action, primarily at the post-receptor level.

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  • It potentiates insulin's suppression of hepatic gluconeogenesis.
  • Metformin increases peripheral glucose uptake and metabolism without stimulating insulin release.

    • Conclusions:

    • Metformin is an effective antihyperglycaemic agent for NIDDM.
    • Its primary action is to improve post-receptor insulin sensitivity.
    • Caution is advised regarding lactate accumulation in patients with renal/liver dysfunction or hypoxia.