Related Experiment Video

Updated: Jul 13, 2026

Yeast As a Chassis for Developing Functional Assays to Study Human P53
14:57

Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

Long noncoding RNAs: p53's secret weapon in the fight against cancer?

Emily Dangelmaier1, Sarah B Lazar1, Ashish Lal1

  • 1Regulatory RNAs and Cancer Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America.

Plos Biology
|February 14, 2019
PubMed

Insights

Long noncoding RNAs (lncRNAs) may mediate the tumor suppressor functions of p53. This study proposes mechanisms for how lncRNAs regulate p53-controlled genes, impacting genome stability.

Area of Science:

  • Molecular Biology
  • Genetics
  • Cancer Research

Background:

  • The tumor suppressor protein p53 regulates numerous genes.
  • No single protein-coding gene has been identified as solely responsible for p53's tumor suppressor activity.
  • This suggests alternative regulatory mechanisms may be involved.

Purpose of the Study:

  • To investigate the potential role of long noncoding RNAs (lncRNAs) in mediating p53's tumor suppressor functions.
  • To propose molecular mechanisms by which lncRNAs regulate p53-target genes.
  • To explore the direct involvement of lncRNAs in maintaining genome stability via p53.

Main Methods:

  • This study is primarily theoretical, proposing molecular mechanisms and hypotheses.
  • It involves literature review and conceptual framework development.
  • No experimental methods were detailed in the abstract.

Main Results:

  • The abstract does not present experimental results.
  • It posits that a subset of p53-regulated genes, controlled by p53-induced lncRNAs, could be key to p53's tumor suppressor function.
  • Hypothesizes a direct role for lncRNAs in p53's genome stability maintenance.

Conclusions:

  • Long noncoding RNAs (lncRNAs) may be essential mediators of p53's function.
  • Understanding lncRNA regulation of p53 could reveal new therapeutic targets for cancer.
  • This framework may also apply to other transcription factors acting through lncRNAs.

More Related Videos

Purification of Ubiquitinated p53 Proteins from Mammalian Cells10:55

Purification of Ubiquitinated p53 Proteins from Mammalian Cells

Published on: March 21, 2022

Detection of Aggregation-Prone Behavior in Mutant P53 V157F Breast Cancer Cells Using Multipoint Thioflavin T Fluorescence04:56

Detection of Aggregation-Prone Behavior in Mutant P53 V157F Breast Cancer Cells Using Multipoint Thioflavin T Fluorescence

Published on: December 30, 2025

Related Concept Videos

Negative Regulator Molecules01:23

Negative Regulator Molecules

Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.
DNA Damage can Stall the Cell Cycle02:36

DNA Damage can Stall the Cell Cycle

In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...
DNA Damage Can Stall the Cell Cycle02:36

DNA Damage Can Stall the Cell Cycle

In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...