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Updated: Jan 29, 2026

A New Single Chamber Implantable Defibrillator with Atrial Sensing: A Practical Demonstration of Sensing and Ease of Implantation
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A New Single Chamber Implantable Defibrillator with Atrial Sensing: A Practical Demonstration of Sensing and Ease of Implantation

Published on: February 28, 2012

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Atrial high rate episodes in patients with cardiac implantable electronic devices: implications for clinical outcomes

Kazuo Miyazawa1, Daniele Pastori2, Yan-Guang Li1,3

  • 1Institute of Cardiovascular Sciences, University of Birmingham, Birmingham, UK.

Clinical Research in Cardiology : Official Journal of the German Cardiac Society
|February 14, 2019
PubMed

Insights

Atrial high rate episodes (AHREs) detected by pacemakers increase stroke and death risk. Adding AHRE data to risk scores significantly improves prediction of these adverse cardiovascular events.

Area of Science:

  • Cardiology
  • Electrophysiology
  • Medical Devices

Background:

  • Atrial high rate episodes (AHREs) detected by cardiac implantable electronic devices (CIEDs) are linked to higher stroke risk.
  • The utility of AHREs in refining existing stroke risk stratification schemes is not fully understood.

Purpose of the Study:

  • To evaluate the prognostic impact of AHREs on cardiovascular events.
  • To determine if AHREs improve the accuracy of stroke risk stratification.

Main Methods:

  • Retrospective analysis of 856 patients with dual-chamber CIEDs.
  • Monitoring for AHREs for 6 months post-implantation.
  • Follow-up for a mean of 4.0 years for thromboembolism and mortality.

Main Results:

  • 14.6% of patients developed AHREs, experiencing high rates of thromboembolism (2.6%/year) and mortality (3.0%/year).
  • AHREs were independently associated with increased risk of thromboembolism (HR 3.40) and death (HR 3.47).
  • While standard scores showed modest predictive ability, adding AHRE data statistically improved risk prediction for composite outcomes.

Conclusions:

  • AHREs are an independent predictor of adverse clinical outcomes.
  • Incorporating AHRE detection into risk scores enhances the prediction of thromboembolism and death.
Abstract

Keywords:
Atrial fibrillationAtrial high rate episodeCardiac implanted electronic deviceRisk stratification scheme

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