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Tissue organizational stability and intercellular invasion.

P B Armstrong1

  • 1Department of Zoology, University of California, Davis 95616.

Ciba Foundation Symposium
|January 1, 1988
PubMed
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Cardiac mesenchyme fibronectin matrix promotes tissue segregation and organizational stability. Its loss leads to intercellular invasion, crucial for understanding tissue development and disease.

Area of Science:

  • Developmental Biology
  • Cell Biology
  • Tissue Engineering

Background:

  • Intercellular invasion, where one tissue intrudes into another, contrasts with tissue segregation, characterized by distinct boundaries.
  • Tissue segregation is an active process observed when dissociated cells reaggregate and reorganize into distinct tissue arrangements.

Purpose of the Study:

  • To investigate the role of the fibronectin-rich interstitial matrix in the segregation of chick embryonic heart tissues (myocardium and mesenchyme).
  • To understand how matrix deposition and loss influence tissue invasion and segregation dynamics.

Main Methods:

  • Studied the sorting-out behavior of reaggregating chick embryonic heart myocardial and mesenchymal cells in vitro.
  • Manipulated fibronectin matrix deposition using culture conditions, growth factors (transforming growth factor-beta), and exogenous matrix.

Related Experiment Videos

  • Observed tissue arrangement and matrix distribution using microscopy.

    • Main Results:

    • A fibronectin-rich matrix, elaborated by cardiac mesenchyme, was selectively present in mesenchyme regions during tissue sorting.
    • Inhibition of matrix deposition prevented tissue segregation.
    • Stimulation of matrix deposition enhanced tissue segregation.
    • Tissue invasion occurred in areas where the mesenchymal fibronectin matrix was lost.

    Conclusions:

    • The fibronectin matrix in cardiac mesenchyme actively promotes tissue segregation and maintains organizational stability.
    • Loss of this fibronectin matrix creates conditions conducive to intercellular invasion, impacting tissue development and potentially disease processes.