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Free radicals and diabetes.

L W Oberley1

  • 1Radiation Research Laboratory, Department of Radiology, University of Iowa, Iowa City 52242.

Free Radical Biology & Medicine
|January 1, 1988
PubMed
Summary

Active oxygen species contribute to Type I diabetes by damaging insulin-producing beta cells. Antioxidant therapies show promise in preventing diabetes and its long-term complications in animal models.

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Area of Science:

  • Endocrinology
  • Immunology
  • Biochemistry

Background:

  • Type I diabetes involves immune-mediated destruction of pancreatic beta cells.
  • Active oxygen species (AOS) are implicated in beta cell damage.
  • AOS may also contribute to diabetic complications.

Purpose of the Study:

  • To review the role of AOS in the pathogenesis of diabetes.
  • To discuss the involvement of AOS in diabetes-related complications.
  • To examine changes in antioxidants during diabetes.

Main Methods:

  • Review of existing literature on AOS and diabetes.
  • Discussion of animal models using alloxan and streptozotocin.
  • Analysis of the effects of oxygen radical scavengers.

Main Results:

  • Immune cell production of AOS contributes to beta cell destruction in Type I diabetes.
  • Alloxan and streptozotocin induce diabetes via AOS production in animal models.
  • Oxygen radical scavengers effectively prevent diabetes in these models.

Conclusions:

  • AOS play a significant role in both the initiation and progression of diabetes.
  • Antioxidant strategies may be beneficial for managing diabetes and its complications.

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