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Related Experiment Videos

Tina Toft Kristensen1, Palle Lyngsie Pedersen2, Jacob Larsen3

  • 1Department of Ear, Nose, Throat and Maxillofacial Surgery, Zealand University Hospital in Køge and Roskilde, Køge, Denmark.

Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme
|February 14, 2019
PubMed
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Hemithyroidectomy reduced thyroid stimulating hormone (TSH) and thyroid hormones, decreasing mitochondrial gene expression. This suggests impaired mitochondrial function in patients post-surgery.

Area of Science:

  • Endocrinology
  • Molecular Biology
  • Mitochondrial Medicine

Background:

  • Hemithyroidectomy can alter thyroid function and mitochondrial activity.
  • Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1α) and PGC-1β are critical regulators of mitochondrial biogenesis.
  • Mitochondrial dysfunction is implicated in various health conditions.

Purpose of the Study:

  • To investigate the longitudinal changes in mRNA expression of PGC-1α and PGC-1β after hemithyroidectomy.
  • To assess alterations in mitochondrial-related genes: NFE2L2, TFAM, and SOD2.
  • To correlate gene expression changes with thyroid hormone levels post-surgery.

Main Methods:

  • Longitudinal study of 28 patients undergoing hemithyroidectomy for benign goiter.

Related Experiment Videos

  • Measurement of TSH and thyroid hormones (fT4, tT3) at baseline and 1, 3, 6, 12 months post-surgery.
  • Whole blood mRNA expression analysis of PGC-1α, PGC-1β, NFE2L2, TFAM, and SOD2 using RT-qPCR.

    • Main Results:

    • TSH levels increased, while triiodothyronine (tT3) declined over one year; free thyroxine (fT4) remained stable.
    • Whole blood PGC-1α and SOD2 mRNA expression significantly decreased post-hemithyroidectomy.
    • No significant changes were observed in PGC-1β, TFAM, or NFE2L2 mRNA levels.

    Conclusions:

    • Hemithyroidectomy leads to significant downregulation of PGC-1α and SOD2 gene expression.
    • Increased TSH within the reference range post-surgery correlates with reduced mitochondrial gene expression.
    • Patients who have undergone hemithyroidectomy may experience impaired mitochondrial function.