Prevention of Recurrent Acute Otitis Media in Children Through the Use of Lactobacillus salivarius PS7, a

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Nivia Cárdenas1, Virginia Martín2, Rebeca Arroyo3

  • 1Department of Nutrition and Food Science, Complutense University of Madrid, 28040 Madrid, Spain. niviacu@yahoo.com.

Nutrients
|February 15, 2019
PubMed

Insights

Lactobacillus salivarius PS7, a probiotic, significantly reduced recurrent acute otitis media (AOM) episodes by 84% in children. This suggests L. salivarius PS7 is a promising approach to prevent AOM and combat antimicrobial resistance.

Area of Science:

  • Microbiology
  • Pediatric Infectious Diseases
  • Gastroenterology

Background:

  • Acute otitis media (AOM) is a common childhood bacterial infection.
  • Antibiotic overuse drives antimicrobial resistance and can disrupt early-life microbiota development.
  • Probiotics offer a potential strategy to restore microbiota and prevent recurrent AOM (rAOM).

Purpose of the Study:

  • To select a probiotic strain, Lactobacillus salivarius PS7, with proven antagonism against otopathogens.
  • To evaluate the efficacy of L. salivarius PS7 in preventing rAOM in children.

Main Methods:

  • Lactobacillus salivarius PS7 was selected for its safety and antimicrobial activity against otopathogens.
  • A clinical trial involved 61 children with rAOM consuming daily ~1 × 10⁸ CFU of L. salivarius PS7.
  • AOM episodes and external auditory canal microbiota were monitored before and during intervention.

Main Results:

  • L. salivarius PS7 demonstrated strong antimicrobial activity against key otopathogens.
  • Children consuming L. salivarius PS7 experienced an 84% reduction in AOM episodes compared to the prior 6-month period.
  • Microbiota analysis showed potential restoration in the external auditory canal.

Conclusions:

  • Lactobacillus salivarius PS7 is a safe and effective probiotic for preventing recurrent AOM in infants and children.
  • This probiotic approach may help mitigate the impact of antibiotic resistance in pediatric infections.
  • Restoration of the nasopharyngeal and middle ear microbiota is a key mechanism for AOM prevention.

Keywords:
Lactobacillus salivariusbacteriocinotitispreventionprobiotic

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