Related Experiment Video

Updated: Jan 29, 2026

Establishing Dual Resistance to EGFR-TKI and MET-TKI in Lung Adenocarcinoma Cells In Vitro with a 2-step Dose-escalation Procedure
09:38

Establishing Dual Resistance to EGFR-TKI and MET-TKI in Lung Adenocarcinoma Cells In Vitro with a 2-step Dose-escalation Procedure

Published on: August 11, 2017

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Treatment exceeds expectations in a patient with non-small cell lung adenocarcinoma with an EGFR exon 20 mutation

Agnes McAuliffe1, Poorva Bindal1, Meredith Haley1

  • 1Department of Medicine, Uconn Health, Farmington, CT, USA.

Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners
|February 15, 2019
PubMed

Insights

Non-small cell lung adenocarcinoma with EGFR exon 20 mutations is challenging to treat with targeted therapies. This case shows chemotherapy can be effective, emphasizing genetic testing for personalized lung cancer treatment.

Area of Science:

  • Oncology
  • Genetics
  • Pharmacology

Background:

  • Non-small cell lung adenocarcinoma (NSCLC) is a prevalent cancer type with treatment challenges.
  • Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) are common treatments, but resistance exists.
  • Certain EGFR mutations, like exon 20 insertions, confer intrinsic resistance to standard TKIs.

Observation:

  • A case study of a 78-year-old male diagnosed with stage IV NSCLC.
  • The patient presented with EGFR exon 20 mutations.
  • Treatment involved pemetrexed, nivolumab, and docetaxel, not TKIs.

Findings:

  • The patient survived over four years post-diagnosis.
  • EGFR exon 20 mutations were associated with poor response to TKIs.
  • Chemotherapeutic agents showed efficacy in this patient.

Implications:

  • Highlights the critical role of comprehensive genetic testing in NSCLC.
  • Suggests chemotherapy may be a viable treatment for NSCLC with EGFR exon 20 mutations.
  • Underscores the need for tailored treatment strategies based on specific EGFR mutation profiles.
Keywords:
EGFR mutationexon 20 mutationlung canceroncologytyrosine kinase inhibitors

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