Related Experiment Video
Updated: Jan 29, 2026
10:12
Construction of Cyclic Cell-Penetrating Peptides for Enhanced Penetration of Biological Barriers
Published on: September 19, 2022
2.8K
Cell-penetrating Peptides: Efficient Vectors for Vaccine Delivery
Jieru Yang1, Yacheng Luo1, Mohini Anjna Shibu1
1School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, QLD 4072, Australia.
Current Drug Delivery
|February 15, 2019
Summary
Cell-penetrating peptides (CPPs) enhance subunit vaccine delivery by improving antigen uptake and presentation. This review explores CPP mechanisms and strategies for advanced vaccine development, addressing adjuvant limitations.
Area of Science:
- Vaccinology
- Immunology
- Biotechnology
Background:
- Subunit vaccines require adjuvants to boost immunogenicity, but current options have limited efficacy and potential toxicity.
- Existing vaccine delivery systems aim to enhance antigen stability and cellular uptake.
Purpose of the Study:
- To review cell-penetrating peptides (CPPs) as a novel component for vaccine delivery systems.
- To explore CPP mechanisms for enhancing antigen delivery and immune response initiation.
Main Methods:
- Review of literature on cell-penetrating peptide (CPP) intercellular uptake mechanisms.
- Analysis of various CPP-based strategies for antigen delivery in vaccine formulations.
Main Results:
- CPPs facilitate enhanced cellular uptake, processing, and presentation of antigens by antigen-presenting cells (APCs).
- CPP fusion or co-delivery with antigens improves fundamental steps in initiating an immune response.
Conclusions:
- CPP-based delivery systems offer a promising strategy to overcome limitations of traditional subunit vaccines and adjuvants.
- Further research into CPP mechanisms and applications can lead to more effective and safer vaccine designs.
Related Concept Videos
01:51Vaccinations
51.5K
Overview
51.5K
02:43Peptide Bonds
82.8K
A peptide bond covalently attaches amino acids through a dehydration reaction. One amino acid's carboxyl group and another amino acid's amino group combine, releasing a water molecule. The resulting bond is the peptide bond. The products that such linkages form are peptides. As more amino acids join this growing chain, the resulting chain is a polypeptide. Each polypeptide has a free amino group at one end. This end has the N-terminal, or the amino-terminal, and the other end has a free...
82.8K
01:30Cancer Vaccines
1.0K
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
1.0K
01:30Vectors
474
Vectors are mathematical entities characterized by both magnitude and direction. Unlike scalars, which are defined solely by magnitude, vectors represent quantities like displacement, velocity, and force, where direction is essential. Vectors are graphically represented as directed line segments, extending from an initial point to a terminal point, denoted with bold letters or arrows placed above the symbol. Two vectors are deemed equal if they share identical magnitudes and directions,...
474
01:30Acceleration Vectors
22.5K
In everyday conversation, accelerating means speeding up. Acceleration is a vector in the same direction as the change in velocity, Δv, therefore the greater the acceleration, the greater the change in velocity over a given time. Since velocity is a vector, it can change in magnitude, direction, or both. Thus acceleration is a change in speed or direction, or both. For example, if a runner traveling at 10 km/h due east slows to a stop, reverses direction, and continues their run at 10 km/h...
22.5K
01:20Vector Operations
2.2K
Vectors are physical quantities that have both magnitude and direction. The vector operations include addition, subtraction, and scalar multiplication.
A vector multiplied by a scalar value is called scalar multiplication. The result obtained is a new vector with a different magnitude. If the scalar is positive, the direction of the vector remains the same, but if it is negative, the direction of the vector is reversed. For example, the product of the mass and velocity yields the momentum.
A vector multiplied by a scalar value is called scalar multiplication. The result obtained is a new vector with a different magnitude. If the scalar is positive, the direction of the vector remains the same, but if it is negative, the direction of the vector is reversed. For example, the product of the mass and velocity yields the momentum.
2.2K