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A High-Yield Streptomyces Transcription-Translation Toolkit for Synthetic Biology and Natural Product Applications
Published on: September 10, 2021
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Biology, biography, and the translational gap
Pamela Summers-Trio1, Allison Hayes-Conroy2, Burton Singer3
1Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA.
Science Translational Medicine
|February 15, 2019
Summary
Medicine-based evidence combines patient biology and biography for personalized care. This approach bridges the gap between medical research and clinical practice, improving patient outcomes.
Area of Science:
- Integrative Medicine
- Translational Science
Background:
- The gap between medical research discoveries and clinical application hinders patient care.
- Personalized medicine requires integrating diverse patient data.
Purpose of the Study:
- To introduce and define medicine-based evidence (MBE).
- To highlight MBE's role in enhancing individual medical care.
- To address the translational gap in healthcare.
Main Methods:
- MBE synthesizes patient biology (e.g., genetics, biomarkers) with biography (e.g., lifestyle, environment, social factors).
- This integration facilitates tailored treatment strategies.
Main Results:
- MBE improves the precision of medical diagnoses and treatments.
- It enhances the effectiveness of healthcare interventions by considering the whole patient.
Conclusions:
- Medicine-based evidence offers a framework for personalized patient care.
- MBE is crucial for closing the research-to-clinic translational gap.
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