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The molecular genetics of complex inherited diseases
1Department of Biochemistry and Molecular Genetics, St. Mary's Hospital Medical School, University of London, Norfolk, UK.
The British Journal of Cancer. Supplement
|December 1, 1988
Abstract:
The majority of inherited diseases are due to unknown biochemical defects, or are either polygenetic or multifactorial. Due to advances in molecular genetics, it is now possible to study these conditions, either by reverse genetics (using cloning techniques to move from linkage to gene, and then determining the protein involved) or by dissecting a complex disease into a set of monogenic paradigms.