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Systemic inflammation during midlife and cognitive change over 20 years: The ARIC Study

Keenan A Walker1, Rebecca F Gottesman2, Aozhou Wu2

  • 1From the Departments of Neurology (K.A.W., R.F.G.) and Epidemiology (R.F.G., A.W., A.L.G., E.S.), Johns Hopkins University, Baltimore, MD; Department of Neurology (D.S.K.), Mayo Clinic, Rochester, MN; Department of Medicine (T.H.M., B.G.W.), Division of Geriatrics, University of Mississippi Medical Center, Jackson. Kwalke26@jhmi.edu.

Neurology
|February 15, 2019
PubMed
Summary

Midlife systemic inflammation, measured by composite scores and C-reactive protein (CRP), is linked to significant 20-year cognitive decline, particularly in memory. This suggests inflammation may drive cognitive aging.

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