Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

DNA Base Pairing

DNA Base Pairing

Erwin Chargaff’s rules on DNA equivalence paved the way for the discovery of base pairing in DNA. Chargaff’s rules state that in a double-stranded DNA molecule,

DNA Base Pairing

DNA Base Pairing

Base-pairing and DNA Repair

Base-pairing and DNA Repair

Relative Strengths of Conjugate Acid-Base Pairs

Relative Strengths of Conjugate Acid-Base Pairs

Brønsted-Lowry acid-base chemistry is the transfer of protons; thus, logic suggests a relation between the relative strengths of conjugate acid-base pairs. The strength of an acid or base is quantified in its ionization constant, Ka or Kb, which represents the extent of the acid or base ionization reaction. For the conjugate acid-base pair HA / A−, the ionization equilibrium equations and ionization constant expressions are

VSEPR Theory and the Effect of Lone Pairs

VSEPR Theory and the Effect of Lone Pairs

Effect of Lone Pairs of Electrons on Molecule Geometry

VSEPR Theory and the Basic Shapes

VSEPR Theory and the Basic Shapes

Overview of VSEPR Theory

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Correlative Multimodal Framework Reveals Supramolecular Chirality Loss Preceding Fibrillar Rarefaction in Dermal Collagen.

ACS nano·2026

Same author

Multifocal Neuroblastoma in Rubinstein-Taybi Syndrome Harboring a Novel CREBBP Variant Identified by Paired Whole Genome Sequencing.

Congenital anomalies·2026

Same author

Coats-like exudative vasculopathy in a patient with Bardet-Biedl syndrome.

American journal of ophthalmology case reports·2026

Same author

Hollow-needle-like nanocarbon with chirality-discriminating inner walls.

Nanoscale·2026

Same author

Comparison of oncological outcomes between robotic and laparoscopic surgeries for gastric cancer: a multi-institutional cohort study in Japan.

Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·2026

Same author

Aberrant Splicing From an HDAC8 Intronic Variant c.112-15C>A Causes Familial Cornelia de Lange Syndrome in Heterozygous and Hemizygous Individuals.

Congenital anomalies·2026

Search research articles

Related Experiment Video

Updated: Jan 29, 2026

Drug Treatment and In Vivo Imaging of Osteoblast-Osteoclast Interactions in a Medaka Fish Osteoporosis Model

Drug Treatment and In Vivo Imaging of Osteoblast-Osteoclast Interactions in a Medaka Fish Osteoporosis Model

Published on: January 1, 2017

Trans-pairing between osteoclasts and osteoblasts shapes the cranial base during development.

Mio Edamoto¹, Yukiko Kuroda¹, Masaki Yoda¹

¹Laboratory of Cell and Tissue Biology, Keio University School of Medicine, Tokyo, 160-8582, Japan.

Scientific Reports

|February 15, 2019

Summary

Mechanical stress from brain growth guides bone remodeling. Osteoclasts and osteoblasts coordinate to shape the basioccipital bone, ensuring proper cranial base development.

More Related Videos

A RANKL-based Osteoclast Culture Assay of Mouse Bone Marrow to Investigate the Role of mTORC1 in Osteoclast Formation

A RANKL-based Osteoclast Culture Assay of Mouse Bone Marrow to Investigate the Role of mTORC1 in Osteoclast Formation

Published on: March 15, 2018

Effect of Anti-c-fms Antibody on Osteoclast Formation and Proliferation of Osteoclast Precursor In Vitro

Effect of Anti-c-fms Antibody on Osteoclast Formation and Proliferation of Osteoclast Precursor In Vitro

Published on: March 18, 2019

Related Experiment Videos

Last Updated: Jan 29, 2026

Drug Treatment and In Vivo Imaging of Osteoblast-Osteoclast Interactions in a Medaka Fish Osteoporosis Model

Drug Treatment and In Vivo Imaging of Osteoblast-Osteoclast Interactions in a Medaka Fish Osteoporosis Model

Published on: January 1, 2017

A RANKL-based Osteoclast Culture Assay of Mouse Bone Marrow to Investigate the Role of mTORC1 in Osteoclast Formation

A RANKL-based Osteoclast Culture Assay of Mouse Bone Marrow to Investigate the Role of mTORC1 in Osteoclast Formation

Published on: March 15, 2018

Effect of Anti-c-fms Antibody on Osteoclast Formation and Proliferation of Osteoclast Precursor In Vitro

Effect of Anti-c-fms Antibody on Osteoclast Formation and Proliferation of Osteoclast Precursor In Vitro

Published on: March 18, 2019

Area of Science:

Developmental biology
Biomechanics
Craniofacial development

Background:

Bone development, particularly the cranial base, is influenced by the expansion of surrounding organs like the brain.
Understanding the mechanisms that link organ growth to bone morphology is crucial for comprehending craniofacial development.

Purpose of the Study:

To investigate the mechanisms underlying morphological changes in the mouse clivus (basioccipital bone) in response to brain enlargement.
To define how mechanical stress influences bone remodeling during cranial base development.

Main Methods:

Histological analysis of mouse basioccipital bone to examine osteoclast and osteoblast distribution.
Finite element analysis to map mechanical stress (compression and tension) on the clivus.
Developmental analysis comparing wild-type mice with Tnfsf11-/- mice lacking osteoclasts.

Main Results:

Osteoclasts were located dorsally and osteoblasts ventrally on the basioccipital bone, corresponding to areas of compression and tension, respectively.
Osteoclastic bone resorption occurred in compressed areas, while bone formation occurred in tension areas.
The clivus angle was less pronounced in mice lacking osteoclasts, indicating their role in shaping the bone.

Conclusions:

Mechanical stresses, specifically compression and tension, dictate the localization of osteoclasts and osteoblasts.
Osteoclast-osteoblast interaction across cortical bone, induced by mechanical stress from growing organs, regulates the shape and size of brain-encasing bones.