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Updated: Jan 29, 2026

Determination of Carbonyl Functional Groups in Bio-oils by Potentiometric Titration: The Faix Method
Published on: February 7, 2017
Total Synthesis of trans-Resorcylide via Macrocyclic Stille Carbonylation
Yiyang Luo1, Xianglin Yin1, Mingji Dai2
1Department of Chemistry, Center for Cancer Research, and Institute for Drug Discovery, Purdue University, 720 Clinic Drive, West Lafayette, IN, 47907, USA.
Abstract:
The resorcylic macrolides are important natural products with a wide range of remarkable biological activities. So far, most of the reported resorcylic macrolide syntheses use either macrolactonization or ring closing metathesis to build the corresponding macrocycle. In continuation of our efforts in developing novel carbonylation reactions to facilitate natural product total synthesis, we report herein a total synthesis of trans-resorcylide (1) featuring a palladium-catalyzed macrocyclic Stille carbonylation to build its 12-membered macrocycle.
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