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Updated: Jan 29, 2026

Prediction of HIV-1 Coreceptor Usage Tropism by Sequence Analysis using a Genotypic Approach
Published on: December 1, 2011
Metabolites predict cardiovascular disease events in persons living with HIV: a pilot case-control study
Nwora Lance Okeke1, Damian M Craig2, Michael J Muehlbauer2
1Division of Infectious Diseases, Department of Medicine, Duke University Medical Center, 315 Trent Drive, Rm. 178, Durham, NC 27710, USA.
Introduction:
Persons living with HIV (PLWH) are at higher risk for cardiovascular disease (CVD) events than uninfected persons. Current risk-stratification methods to define PLWH at highest risk for CVD events are lacking.
Methods:
Using tandem flow injection mass spectrometry, we quantified plasma levels of 60 metabolites in 24 matched pairs of PLWH [1:1 with and without known coronary artery disease (CAD)]. Metabolite levels were reduced to interpretable factors using principal components analysis.
Results:
Factors derived from short-chain dicarboxylacylcarnitines (SCDA) (p = 0.08) and glutamine/valine (p = 0.003) were elevated in CAD cases compared to controls.
Conclusion:
SCDAs and glutamine/valine may be valuable markers of cardiovascular risk among persons living with HIV in the future, pending validation in larger cohorts.
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