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Generation of Human 3D Lung Tissue Cultures 3D-LTCs for Disease Modeling
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Type 3 ILCs in Lung Disease.

Amanda Ardain1,2, James Zachary Porterfield1,2,3, Henrik N Kløverpris1,4,5

  • 1Africa Health Research Institute, Durban, South Africa.

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|February 15, 2019
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Summary

Innate lymphoid cells (ILCs), particularly ILC3s, are crucial for lung health and immunity. This review explores their role in infectious and inflammatory lung diseases, focusing on human data.

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COPDILC3airway hypersensitivitylung diseasepnemoniapulmonary fibrosistuberulosis

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Area of Science:

  • Immunology
  • Respiratory Medicine

Background:

  • The lungs are a complex immune environment requiring a balance between external signals and protective responses.
  • Innate lymphoid cells (ILCs) are vital for tissue repair, homeostasis, and immunity at mucosal surfaces, including the lungs.
  • While ILC2s are established players in asthma and parasitic infections, the role of ILC3s in respiratory diseases is less understood.

Purpose of the Study:

  • To review the emerging role of Innate lymphoid cells type 3 (ILC3s) in infectious and inflammatory lung diseases.
  • To highlight the importance of the IL17/IL22 axis in lung health.
  • To focus on data derived from human subjects regarding ILC3 function in the lungs.

Main Methods:

  • Literature review of existing research on ILCs in lung immunity.
  • Analysis of data focusing on ILC3 involvement in respiratory conditions.
  • Synthesis of findings related to human subjects and ILC3s.

Main Results:

  • ILC3s are critical for homeostasis, infection control, and inflammation modulation at mucosal barriers.
  • The IL17/IL22 signaling pathway, involving ILC3s, is essential for maintaining lung health.
  • Emerging evidence suggests a significant role for ILC3s in human infectious and inflammatory lung diseases.

Conclusions:

  • ILC3s are increasingly recognized as key mediators in the lung's immune response to infection and inflammation.
  • Further research into ILC3s offers potential therapeutic targets for respiratory diseases.
  • Human data underscores the clinical relevance of ILC3s in lung pathology.