Renal mineralocorticoid receptor expression is reduced in lipoatrophy

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Barbara Toffoli1, Stella Bernardi2, Carine Winkler1

  • 1Center for Integrative Genomics Faculty of Biology and Medicine University of Lausanne Switzerland.

FEBS Open Bio
|February 15, 2019
PubMed

Insights

Obesity impacts cardiovascular health partly through adipose tissue secretions. This study reveals that adipose tissue, potentially via the leptin system, influences mineralocorticoid receptor (MR) expression in the kidneys.

Area of Science:

  • Endocrinology
  • Cardiovascular Science
  • Metabolic Research

Background:

  • Obesity is a major global health issue linked to cardiovascular disease (CVD).
  • Adipose tissue secretes factors that may mediate obesity's link to CVD.
  • The role of adipose tissue in regulating mineralocorticoid receptor (MR) expression is unclear.

Purpose of the Study:

  • To investigate the hypothesis that adipose tissue and its secretory products influence mineralocorticoid receptor (MR) expression.
  • To explore the potential role of the leptin system in this regulation.

Main Methods:

  • Analysis of MR and its downstream target gene expression in the kidneys of genetically modified mouse models (lipoatrophic and obese).
  • Comparison of gene expression in disease models versus control groups.

Main Results:

  • Significantly reduced expression of MR and downstream targets (Cnksr3, Scnn1b, Sgk1) in the kidneys of lipoatrophic mice (Pparg null and AZIPtg/+).
  • Significantly reduced MR expression observed in the kidneys of genetically obese ob/ob mice.
  • Leptin deficiency is a common feature in these models, suggesting a role for the leptin system.

Conclusions:

  • Adipose tissue contributes to the regulation of kidney mineralocorticoid receptor (MR) expression.
  • The leptin system is a potential mediator through which adipose tissue modulates MR expression.
Keywords:
kidneylipoatrophymineralocorticoid receptorobesity

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