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MGL Ligand Expression Is Correlated to Lower Survival and Distant Metastasis in Cervical Squamous Cell and

Neha M Sahasrabudhe1, Joost C van der Horst1, Vivian Spaans2,3

  • 1Department of Molecular Cell Biology and Immunology, Cancer Center Amsterdam, Amsterdam Infection & Immunity Institute, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.

Frontiers in Oncology
|February 15, 2019
PubMed

Insights

Aberrant glycosylation, marked by MGL ligand expression, is linked to poor cervical cancer outcomes. This finding highlights a potential immune evasion mechanism involving MGL in cervical tumors.

Area of Science:

  • Oncology
  • Immunology
  • Glycobiology

Background:

  • Cervical cancer is a leading cause of cancer death in women globally.
  • The tumor microenvironment in cervical cancer is highly immune-suppressive.
  • Aberrant glycosylation is increasingly recognized as a key factor in cancer progression.

Purpose of the Study:

  • To investigate the role of aberrant glycosylation, specifically MGL ligand expression, in the immune-suppressive microenvironment of cervical cancer.
  • To determine the prognostic significance of MGL ligand expression in cervical squamous cell carcinoma (SCC) and adenosquamous carcinoma (ASC).

Main Methods:

  • Analysis of MGL ligand expression in cervical cancer tissues.
  • Correlation of MGL ligand expression with patient survival, recurrence, and metastasis.
  • Assessment of immune cell populations (CD14+, CD163+) and PIK3CA mutations in relation to MGL ligand expression.

Main Results:

  • MGL ligand expression is associated with poor disease-specific survival and increased distant recurrences in SCC and ASC.
  • MGL ligand expression correlates with lymph node metastasis and specific myeloid cell profiles (absence of CD14+, presence of CD14-CD163+).
  • MGL ligand expression is linked to PIK3CA mutations, a common oncogenic alteration in cervical cancer.

Conclusions:

  • MGL ligand expression serves as a prognostic marker in cervical SCC/ASC patients.
  • The C-type lectin MGL plays a role in immune evasion within the cervical tumor microenvironment.
  • Aberrant glycosylation via MGL interaction contributes to cervical cancer progression and immune suppression.
Keywords:
MGLcervical cancerdistant metastasisglycosylationhistological subtype

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