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Published on: June 19, 2015
Insights into the anti-infective properties of prodiginines
Zhongyu You1, Suping Zhang2, Xiaoxia Liu3
1College of Biological, Chemical Sciences and Engineering, Jiaxing University, No. 118 Jiahang Road, Jiaxing, Zhejiang, 314001, People's Republic of China. elmer0718@163.com.
Abstract:
Prodiginines are a large family of tripyrrole alkaloids that contain natural members produced by various bacteria and non-natural members obtained from chemical synthesis, enzymatic synthesis, and mutasynthesis. These compounds have attracted a great deal of attention due to their wide range of fascinating properties including anti-infective, anticancer, and immunosuppressive activities. In consideration of the great need for novel and effective anti-infective agents, this review is mainly focused on the current status of research on the anti-infective properties of prodiginines, highlighting their antibacterial, antifungal, antiprotozoal, anti-larval, and antiviral activities. Additionally, the multiple mechanisms by which prodiginines exert their anti-infective effects will also be discussed.
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