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Role of DIDO1 in Progression of Esophageal Squamous Cell Carcinoma

Mohammad Mahdi Forghanifard1, Pegah Naeimi Khorasanizadeh2, Mohammad Reza Abbaszadegan2

  • 1Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran.

Journal of Gastrointestinal Cancer
|February 15, 2019
PubMed
Abstract

Insights

Death inducer-obliterator 1 (DIDO1) expression was analyzed in esophageal squamous cell carcinoma (ESCC). DIDO1 may play a role in early tumor progression and could serve as a marker for primary ESCC.

Area of Science:

  • Molecular biology
  • Cancer research
  • Apoptosis

Background:

  • Apoptosis is crucial for development and organogenesis; its dysregulation can lead to cancer.
  • Death inducer-obliterator 1 (DIDO1) is involved in activating caspases during apoptosis.

Purpose of the Study:

  • To investigate the role of DIDO1, the shortest splicing variant of the DIDO gene, in esophageal squamous cell carcinoma (ESCC).
  • To assess DIDO1 expression in ESCC patients for the first time.

Main Methods:

  • Real-time polymerase chain reaction (RT-PCR) was used to measure DIDO1 mRNA expression.
  • DIDO1 mRNA levels in tumor tissues were compared to adjacent normal tissues from 50 ESCC patients.

Main Results:

  • DIDO1 under- and overexpression were observed in 18% and 26% of ESCC cases, respectively.
  • Significant correlations were found between DIDO1 mRNA expression and tumor depth of invasion (p = 0.050).
  • A significant correlation was also noted between patient age and DIDO1 mRNA levels (p = 0.039).

Conclusions:

  • This study is the first to report DIDO1 expression in ESCC.
  • DIDO1 likely contributes to the early stages of tumor progression and metastasis in ESCC.
  • DIDO1 is a potential biomarker for primary ESCC.
Keywords:
ApoptosisESCCMetastasisReal-time PCRTumor

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