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An exploratory study of the relationship between postoperative nausea and vomiting and postdischarge nausea and
Arvind Chandrakantan1, Ruth A Reinsel2, Ronald Jasiewicz3
1Department of Anesthesiology, Baylor College of Medicine, Houston, Texas.
Insights
Postoperative nausea and vomiting (PONV) can continue after discharge in children. Pain and male gender were linked to nausea at discharge, while nausea at discharge predicted further vomiting and nausea post-discharge.
Area of Science:
- Pediatric Anesthesiology
- Surgical Outcomes Research
- Patient Recovery Monitoring
Background:
- Postoperative nausea and vomiting (PONV) is a common concern in pediatric surgery.
- Previous research has focused on in-hospital PONV, with limited data on postdischarge symptoms.
- The factors influencing nausea and vomiting after a child leaves the hospital remain largely unstudied.
Purpose of the Study:
- To investigate the incidence and predictors of postdischarge nausea and vomiting (PDNV) in pediatric patients.
- To determine if factors associated with in-hospital PONV contribute to PDNV.
- To identify specific risk factors for PDNV in ambulatory pediatric surgery patients.
Main Methods:
- A preliminary study involving 122 pediatric patients (aged 5-10 years) undergoing elective ambulatory surgery.
- Child self-ratings of nausea and pain were collected preoperatively, at discharge, and for 3 days postdischarge.
- Stepwise logistic regression analysis was used to identify predictors of nausea and emesis at different time points.
Main Results:
- Nearly half of the children (47%) experienced nausea at discharge, and 11% had emesis on the day of surgery.
- Nausea at discharge was associated with male gender and pain at discharge.
- Nausea at discharge predicted emesis on the day of surgery and nausea on postoperative day 1.
Conclusions:
- Postoperative nausea and vomiting can extend into the postdischarge period for pediatric patients.
- Pain experienced by the child at discharge is a significant factor contributing to PDNV.
- Further research is warranted to understand and manage PDNV effectively.
Background:
The factors contributing to postoperative nausea and vomiting in children have been identified, but there have been no reported studies that have studied pediatric postdischarge nausea and vomiting.
Aims:
This preliminary study aimed to identify the factors affecting postdischarge nausea and vomiting in ambulatory children, specifically whether postoperative nausea and vomiting factors are contributory.
Methods:
One hundred and twenty-two pediatric patients aged 5-10 years undergoing elective ambulatory surgery participated in this institution-approved study. After obtaining written parental consent and patient assent when indicated, child self-ratings of nausea and pain were completed preoperatively and at discharge, and for 3 days postdischarge. Questionnaires were returned by mail, with a 64% return rate. Using stepwise logistic regression with backward elimination, three separate analyses were undertaken to predict the following outcomes: nausea present in recovery, nausea present on postoperative day 1, and emesis on day of surgery.
Results:
Nearly half (47%) of our cohort experienced nausea at the time of discharge; 11% had emesis on day of surgery. On postoperative day 1, there was a 15% incidence of nausea with a 3% incidence of emesis. In the multiple logistic regression analyses, nausea at discharge was predicted by male gender (odds ratio 2.5, 95% CI: 1.0-6.2) and the presence of pain on discharge (odds ratio 3.0, 95% CI: 1.0-9.2). Emesis on day of surgery was predicted by the presence of nausea at discharge (odds ratio 16.9, 95% CI: 1.8-159.3) and having a family history of nausea/vomiting (odds ratio 8.3, 95% CI: 1.6-43.4). The presence of nausea on postoperative day 1 was predicted only by the presence of nausea on discharge (odds ratio 3.7, 95% CI: 1.2-11.1).
Conclusion:
Our preliminary data indicate that postoperative nausea and vomiting may persist into the postdischarge period and pain may be a contributing factor.
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