Related Experiment Video
Updated: Jan 29, 2026

Quantifying the Binding Interactions Between CuII and Peptide Residues in the Presence and Absence of Chromophores
Published on: April 5, 2022
Role of Mono- and Divalent Ions in Peptide Glu-Asp-Arg-DNA Interaction
Irina A Silanteva1, Andrei V Komolkin1, Ekaterina A Morozova1
1Faculty of Physics , Saint Petersburg State University , 7-9 Universitetskaya embankment , Saint Petersburg 199034 , Russia.
Abstract:
The interaction of the regulatory biologically active peptide Glu-Asp-Arg (EDR) with DNA is considered by spectral, NMR, viscosimetry, and molecular dynamics methods. It was shown that EDR can partly penetrate into the major groove of DNA and affect the base atoms, mainly the N7 and O6 of guanine. It was observed that Mg2+ ions can promote DNA-EDR interaction due to their effective screening of the negatively charged phosphate groups of DNA. This action of Mg2+ remains in salted solution as well.
Related Concept Videos
The Role of Ion Channels in Neuronal Computation
Sometimes a single EPSP is strong enough to induce an action potential in the postsynaptic neuron. However, multiple presynaptic inputs must often create EPSPs around the same time for the postsynaptic neuron to be sufficiently depolarized to fire an action potential....
Trends in Lattice Energy: Ion Size and Charge
Peptide Bonds
Common Ion Effect
Precipitation of Ions
The equation that describes the equilibrium between solid calcium carbonate and its solvated ions is:
Ion Channels
Ion channels are specialized integral membrane proteins on the plasma membrane that allow...

