Can EEG Predict Response to Atomoxetine in attention deficit hyperactivity disorder at 1 Week?

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Published on: June 12, 2020

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Gurmukh Singh1, Priti Arun1, Subhash Das1

  • 1Government Medical College & Hospital, Chandigarh, India.

Journal of Attention Disorders
|February 15, 2019
PubMed

Insights

Electroencephalography (EEG) changes at 1 week can predict treatment response in children with Attention-Deficit/Hyperactivity Disorder (ADHD). Decreased theta cordance values indicate likely positive response to atomoxetine therapy.

Area of Science:

  • Neuroscience
  • Child Psychiatry
  • Pharmacology

Background:

  • Attention-Deficit/Hyperactivity Disorder (ADHD) is a common neurodevelopmental disorder in children.
  • Atomoxetine is a commonly prescribed medication for ADHD.
  • Predicting treatment response early can optimize therapeutic outcomes.

Purpose of the Study:

  • To investigate early electroencephalography (EEG) changes after 1 week of atomoxetine treatment in children with ADHD.
  • To correlate these early EEG changes with clinical response at 6 weeks.
  • To identify potential biomarkers for predicting atomoxetine efficacy.

Main Methods:

  • Fifty children (6-14 years) diagnosed with ADHD according to DSM-5 criteria participated.
  • Clinical response was assessed using Vanderbilt ADHD Parent and Teacher Rating Scales (VADPRS/VADTRS) at baseline and at 1, 4, and 6 weeks.
  • Electroencephalography (EEG) was recorded at baseline and 1 week post-treatment using the International 10-20 System.

Main Results:

  • Patients were categorized as responders or non-responders based on clinical scales.
  • Responders showed a significant decrease in theta cordance values after 1 week of atomoxetine.
  • Non-responders did not exhibit a significant decrease in theta cordance values.

Conclusions:

  • Decreased theta cordance values at 1 week predict a positive clinical response to atomoxetine in children with ADHD.
  • Specifically, changes in the left temporoparietal region are indicative of response.
  • This EEG marker may aid in early identification of non-responders, allowing for timely treatment adjustments.

Keywords:
EEGatomoxetinecordanceresponders

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