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Updated: Jan 29, 2026

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Coagulation factor XIII-A and activated FXIII-A decrease in some deep vein thrombosis patients following

Woosuk S Hur1, Hannah Warner2, Lindsay Machan2

  • 1Michael Smith Laboratories, Department of Biochemistry and Molecular Biology, University of British Columbia.

Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis
|February 15, 2019
PubMed

: The objective of the study was to assess the effect of tissue plasminogen activator administered during catheter-directed thrombolysis (CDT) on coagulation factor XIII (FXIII). Thrombolytic therapy carries significant risks, such as life-threatening bleeds. The mechanisms responsible for major bleeds and intracerebral hemorrhages during thrombolysis are not fully understood. Activated FXIII (FXIII-A) lies at the intersection of coagulation and fibrinolysis. Using purified proteins and blood collected from nine deep vein thrombosis patients undergoing CDT, the stability of FXIII-A and FXIII were measured immediately before, immediately after and 1-day post thrombolysis. We found that purified tissue plasminogen activator directly degraded FXIII-A. During CDT, FXIII levels were decreased by more than 40% in five of nine patients and FXIII-A levels were decreased by more than 85% in two patients when it was activated. FXIII-A and FXIII-A can decrease during CDT in some patients, warranting further research into the role of FXIII-A in bleeding from thrombolysis.

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