Related Experiment Video

Updated: Jan 29, 2026

Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment
08:36

Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment

Published on: April 19, 2024

1.2K

Efficacy of tolvaptan for chronic heart failure: Study protocol for a systematic review of randomized controlled

Wei-Qin Gao1, Xiang-Dong Meng, Ze Sun

  • 1First Ward of Cardiology Department, First Affiliated Hospital of Jiamusi University, Jiamusi, China.

Medicine
|February 15, 2019
PubMed

Insights

This systematic review will evaluate tolvaptan

Area of Science:

  • Cardiology
  • Pharmacology
  • Systematic Reviews

Background:

  • Chronic heart failure (CHF) poses a significant global health burden.
  • Tolvaptan is a vasopressin receptor antagonist explored for CHF management.
  • Existing evidence on tolvaptan's efficacy and safety in CHF requires systematic synthesis.

Purpose of the Study:

  • To systematically evaluate the efficacy and safety of tolvaptan in treating patients with chronic heart failure (CHF).
  • To synthesize current evidence from randomized controlled trials (RCTs) on tolvaptan for CHF.

Main Methods:

  • Comprehensive literature search of multiple electronic databases (PubMed, Embase, Cochrane, Web of Science, Scopus, etc.) from inception to February 1, 2019.
  • Inclusion of randomized controlled trials (RCTs) assessing tolvaptan in CHF patients.
  • Independent study selection, data extraction, and quality assessment by two authors.

Main Results:

  • The study will compare tolvaptan's efficacy and safety against standard treatments in CHF.
  • Key outcomes include all-cause mortality, body weight changes, urine output, serum sodium levels, and adverse event incidence.
  • A meta-analysis of pooled data will provide quantitative estimates of tolvaptan's effects.

Conclusions:

  • This systematic review will provide a comprehensive summary of the evidence on tolvaptan for CHF.
  • Findings will inform clinical decision-making regarding tolvaptan use in heart failure management.
  • The study aims to identify potential benefits and risks associated with tolvaptan therapy.
Abstract

More Related Videos

Author Spotlight: Advancements and Challenges in Surgical Treatments for Postamputation Pain03:26

Author Spotlight: Advancements and Challenges in Surgical Treatments for Postamputation Pain

Published on: March 8, 2024

3.5K
Author Spotlight: Regenerative Peripheral Nerve Interface (RPNI) Surgery in Postamputation Pain Management03:53

Author Spotlight: Regenerative Peripheral Nerve Interface (RPNI) Surgery in Postamputation Pain Management

Published on: March 15, 2024

2.9K

Related Concept Videos

Random and Systematic Errors01:20

Random and Systematic Errors

Scientists always try their best to record measurements with the utmost accuracy and precision. However, sometimes errors do occur. These errors can be random or systematic. Random errors are observed due to the inconsistency or fluctuation in the measurement process, or variations in the quantity itself that is being measured. Such errors fluctuate from being greater than or less than the true value in repeated measurements. Consider a scientist measuring the length of an earthworm using a...
14.8K
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
872
Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
3.5K
Heart Failure I: Introduction01:27

Heart Failure I: Introduction

Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
847
Heart Failure VI: Adjunct Therapies01:22

Heart Failure VI: Adjunct Therapies

Additional therapies for treating patients with heart failure (HF) may include procedural interventions, supplemental oxygen, the management of sleep disorders, and nutritional therapy.Procedural InterventionsImplantable Cardioverter-Defibrillator: For patients at risk of life-threatening arrhythmias due to severe left ventricular dysfunction, an Implantable Cardioverter-Defibrillator (ICD) can detect and terminate these arrhythmias, preventing sudden cardiac death and improving survival rates.
314
Heart Failure Drugs: Diuretics01:22

Heart Failure Drugs: Diuretics

Heart failure and kidney perfusion are interconnected in a complex way. Reduced renal perfusion and venous congestion are two significant factors that contribute to renal dysfunction in heart failure. The kidneys, primarily responsible for fluid balance in the body, are adversely affected due to compromised cardiac output and increased venous pressure. In response to reduced renal perfusion, the kidneys activate neurohumoral mechanisms to restore balance. However, these mechanisms can be...
948