Related Experiment Video

Updated: Jan 29, 2026

Intra-Peritoneal Transplantation for Generating Acute Myeloid Leukemia in Mice
10:02

Intra-Peritoneal Transplantation for Generating Acute Myeloid Leukemia in Mice

Published on: January 6, 2023

2.5K

Current challenges for CAR T-cell therapy of acute myeloid leukemia

Tim Sauer1, Cliona M Rooney1,2,3,4

  • 1Center for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, and Baylor College of Medicine, Houston, Texas.

Transfusion
|February 15, 2019
PubMed

Insights

Chimeric antigen receptor (CAR) T-cell therapy shows promise for acute myeloid leukemia (AML). Identifying specific targets and overcoming immune escape are key challenges for successful CAR T-cell treatment in AML patients.

Area of Science:

  • Immunotherapy
  • Hematologic Malignancies
  • Cellular Therapy

Background:

  • Acute myeloid leukemia (AML) has a poor prognosis, necessitating novel therapeutic strategies.
  • Chimeric antigen receptor (CAR) T-cell therapy offers a promising avenue for treating AML.
  • A significant hurdle in CAR T-cell therapy for AML is the identification of suitable leukemia-specific antigens.

Purpose of the Study:

  • To highlight the potential of CAR T-cell therapy in improving outcomes for AML patients.
  • To identify the critical challenges hindering the efficacy of CAR T-cell therapy in AML.
  • To discuss strategies for overcoming immune escape mechanisms in CAR T-cell therapy for AML.

Main Methods:

  • Review of current literature on CAR T-cell therapy for AML.
  • Analysis of antigen identification strategies for leukemia-specific targets.
  • Examination of immune escape mechanisms, including antigen downregulation and tumor microenvironment suppression.

Main Results:

  • CAR T-cell therapy holds significant potential for AML treatment.
  • Lack of specific leukemia targets and immune evasion limit therapeutic success.
  • Downregulation of target antigens and a suppressive tumor microenvironment are major obstacles.

Conclusions:

  • Target antigen identification is crucial for effective CAR T-cell therapy in AML.
  • Overcoming immune escape mechanisms is essential for durable responses.
  • Further research is needed to optimize CAR T-cell therapy for AML patients.

More Related Videos

Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up09:01

Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up

Published on: March 26, 2018

14.7K
Studying Interactions between Myeloid Cells and CAR T Cells In Vitro and In Vivo05:14

Studying Interactions between Myeloid Cells and CAR T Cells In Vitro and In Vivo

Published on: July 25, 2025

840

Related Concept Videos

Differentiation of Common Myeloid Progenitor Cells01:15

Differentiation of Common Myeloid Progenitor Cells

Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
4.0K
Gene Therapy00:59

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
27.6K
Electrical Current01:10

Electrical Current

Electrical current is defined as the rate at which charge flows. When there is a large current present, such as that used to run a refrigerator, a large amount of charge moves through the wire in a small amount of time. If the current is small, such as that used to operate a handheld calculator, a small amount of charge moves through the circuit over a long period of time. The SI unit for current is the ampere (A), named for the French physicist André-Marie Ampère (1775–1836).
7.1K
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.7K
Group Therapy01:26

Group Therapy

Group therapy is a sociocultural approach to psychological treatment, where individuals with shared psychological challenges come together under the guidance of a mental health professional. This therapeutic modality offers unique opportunities for individuals to connect, share, and grow within the context of a supportive group. By fostering mutual understanding and collaboration, group therapy can address a range of psychological concerns effectively, often complementing or surpassing the...
423
Current Density01:21

Current Density

The total amount of current flowing through one unit value of a cross-sectional area is referred to as current density. If the current flow is uniform, the amount of current flowing through a conductor is the same at all points along the conductor, even if the conductor area varies. The current density consists of the local magnitude and direction of the charge flow, which varies from point to point. Current density is measured in amperes per meter square, and direction is defined as the net...
5.1K