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Update on central precocious puberty: from etiologies to outcomes
Sena Cantas-Orsdemir1, Erica A Eugster2
1a Department of Pediatrics/Division of Pediatric Endocrinology , University of California School of Medicine , Orange , CA , USA.
Expert Review of Endocrinology & Metabolism
|February 15, 2019
Summary
Central precocious puberty (CPP) treatment advances with gonadotropin-releasing hormone analogs (GnRHas). Ongoing research addresses diagnostic uncertainties, genetic causes, and long-term outcomes, especially in boys and the psychological impact on girls.
Area of Science:
- Pediatric Endocrinology
- Reproductive Endocrinology
- Genetics
Background:
- Precocious puberty (PP) is a common pediatric endocrine referral.
- Gonadotropin-releasing hormone analogs (GnRHas) are the standard treatment for central precocious puberty (CPP).
- Advancements in diagnosis and management are continuously improving clinical care.
Purpose of the Study:
- To review current diagnostic considerations and controversies in CPP.
- To discuss new findings on CPP etiology and treatment.
- To highlight areas needing further research.
Main Methods:
- Literature review of recent advancements in CPP diagnosis and treatment.
- Analysis of emerging evidence on monogenic etiologies.
- Evaluation of newer GnRHa formulations and their long-term outcomes.
Main Results:
- Emerging evidence points to monogenic causes of CPP.
- Newer extended-release GnRHa formulations show promise, but long-term comparative data is limited.
- Knowledge gaps persist regarding CPP in boys and psychological effects in girls.
Conclusions:
- Continued research is vital for understanding CPP genetics and optimizing treatment strategies.
- Further investigation is needed to address uncertainties in diagnosis and long-term outcomes of newer GnRHa preparations.
- More research is required on CPP in boys and the psychological impact on girls.
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