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Whipple's Disease: A Case Report.

Orkide Kutlu¹, Selma Şengiz Erhan², Yasemin Gökden³

¹Department of Internal Medicine, Okmeydanı Education and Research Hospital, Istanbul, Turkey, orkidekutlu@windowslive.com.

Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre

|February 15, 2019

Summary

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Whipple's disease is a rare, potentially fatal infection. Early diagnosis through histopathology and PCR is crucial, especially in patients with severe malabsorption, even without typical symptoms.

Area of Science:

Gastroenterology
Infectious Diseases
Microbiology

Background:

Whipple's disease is a rare systemic bacterial infection with a low incidence.
Untreated, it can lead to severe malabsorption and potentially fatal outcomes.

Observation:

A 49-year-old patient presented with severe malabsorption symptoms.
The patient lacked the classic accompanying features often associated with Whipple's disease.

Findings:

Diagnosis was confirmed via histopathological examination of small intestine biopsies.
Polymerase chain reaction (PCR) analysis further supported the diagnosis of Whipple's disease.

Implications:

Clinicians should consider Whipple's disease in the differential diagnosis of severe malabsorption.

Keywords:

Malabsorption Tropheryma whipplei Whipple’s disease

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Timely diagnosis and treatment are essential for patient outcomes, even in atypical presentations.