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Assessment of Vascular Function in Patients With Chronic Kidney Disease
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Relationship between plasma YKL-40 levels and endothelial dysfunction in chronic kidney disease

Gül Sema Keskin, Özant Helvacı, Çağrı Yayla

    Turkish Journal of Medical Sciences
    |February 16, 2019
    PubMed

    Insights

    YKL-40 levels increase with chronic kidney disease (CKD) progression and are linked to endothelial dysfunction. Higher YKL-40 correlates with lower kidney function and impaired blood vessel function.

    Area of Science:

    • Nephrology
    • Cardiovascular Research
    • Biomarkers

    Background:

    • Chronic kidney disease (CKD) is associated with increased cardiovascular risk.
    • Endothelial dysfunction is a key factor in CKD complications.
    • YKL-40 is a potential inflammatory biomarker.

    Purpose of the Study:

    • To investigate the relationship between YKL-40 levels and endothelial dysfunction in CKD patients.
    • To assess YKL-40 levels across different stages of CKD, including hemodialysis (HD).

    Main Methods:

    • Cross-sectional study including 29 HD patients, 101 non-dialytic CKD patients, and 38 healthy controls.
    • YKL-40 levels measured using ELISA.
    • Endothelial function assessed via brachial artery flow-mediated dilation (FMD).

    Main Results:

    • YKL-40 levels were significantly elevated in CKD patients compared to controls, with the highest levels in HD patients (P=0.001).
    • FMD values were significantly lower in non-dialytic CKD and HD patients (P=0.001).
    • YKL-40 showed a negative correlation with estimated glomerular filtration rate (eGFR) (r=–0.674) and FMD (r=–0.471).

    Conclusions:

    • YKL-40 levels increase progressively with CKD severity.
    • Elevated YKL-40 is associated with endothelial dysfunction in CKD patients.
    • YKL-40 may serve as a biomarker for endothelial dysfunction in CKD.

    Keywords:
    YKL-40CKDhemodialysisatherosclerosisendothelial dysfunction

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