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Related Concept Videos

Gene Therapy00:59

Gene Therapy

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Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
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Cancer Therapies02:49

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
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Targeted Cancer Therapies02:57

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Cancer-Critical Genes II: Tumor Suppressor Genes01:05

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Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
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Such genes that act...
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The Thyroid Gland01:23

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The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
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Spontaneous Murine Model of Anaplastic Thyroid Cancer
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Gene therapy for thyroid cancer.

Augusto Taccaliti1, Monia Pacenti2, Matteo Bruglia3

  • 1a Division of Endocrinology, University of Ancona, Via Conca, I-60100, Ancona, Italy. a.taccaliti@univpm.it.

Expert Review of Endocrinology & Metabolism
|February 16, 2019
PubMed
Summary

Gene therapy offers a promising alternative for advanced thyroid cancers resistant to conventional treatments. Combining gene therapy with existing methods may improve patient outcomes.

Keywords:
gene therapyproto-oncogenesthyroid cancerthyroid markerstumor suppressor genesviral vectors

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Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Most thyroid cancers are treatable with surgery and radioactive iodine (I-131).
  • A significant minority (10-20%) of patients develop advanced tumors unresponsive to standard therapies.
  • This necessitates exploring novel treatment strategies for refractory thyroid cancer.

Purpose of the Study:

  • To review the potential of gene therapy for advanced thyroid cancer.
  • To highlight the feasibility of targeted therapeutic gene delivery in preclinical models.
  • To emphasize the importance of combined and multimodality approaches for clinical success.

Main Methods:

  • Review of preclinical studies on gene therapy strategies for thyroid cancer.
  • Analysis of targeted therapeutic gene delivery systems.
  • Evaluation of combined gene therapy and conventional treatment regimens.

Main Results:

  • Several gene therapy strategies have shown preclinical feasibility for thyroid cancer.
  • Targeted gene delivery shows promise for overcoming treatment resistance.
  • Combined gene therapy approaches are suggested for enhanced clinical efficacy.

Conclusions:

  • Gene therapy represents a viable alternative for advanced thyroid cancers.
  • Multimodality treatment combining gene therapy with conventional methods is recommended.
  • Emerging thyroid cancer markers could further enhance gene therapy effectiveness.