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Steroid hormone receptors and oncogenes
1Department of Biochemistry, College of Agriculture and Life Sciences, University of Wisconsin, Madison 53706.
Biofactors (Oxford, England)
|January 1, 1988
Summary
Steroid receptors and oncogene products are transcription factors regulating cell growth. Similarities suggest these molecules have important inter-relationships in normal and malignant differentiation.
Area of Science:
- Molecular Biology
- Endocrinology
- Oncology
Background:
- Steroid hormones regulate growth via intracellular receptors that modulate gene transcription.
- Viral oncogenes (v-oncs) and cellular oncogenes (proto-oncogenes) are implicated in cell transformation and normal growth.
- Steroid hormones and oncogene products influence cancer cell growth and differentiation.
Purpose of the Study:
- To review the similarities and functional interactions between steroid receptors and oncogene products.
- To explore their roles in regulating normal and malignant growth and differentiation.
Main Methods:
- Comparative analysis of amino acid sequences between steroid receptors and oncogene products.
- Review of existing literature on functional interactions and regulatory roles.
Main Results:
- Steroid receptors share sequence similarities with the erb-A oncogene product, identified as a thyroid hormone receptor.
- This suggests steroid receptors and the erb-A product belong to a superfamily of transcription factors.
- Evidence points to inter-relationships between steroid receptors and oncogene products in cellular regulation.
Conclusions:
- Steroid receptors and oncogene products represent a superfamily of transcription factors.
- These molecules play crucial roles in regulating normal and malignant growth and differentiation.
- Further investigation into their inter-relationships is warranted.