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Intestinal phosphate absorption: The paracellular pathway predominates?

Matthew Saurette1,2, R Todd Alexander1,2,3

  • 11 Department of Physiology, University of Alberta, Edmonton, Alberta T6G 2R7, Canada.

Experimental Biology and Medicine (Maywood, N.J.)
|February 16, 2019
PubMed
Summary
This summary is machine-generated.

Transcellular intestinal phosphate absorption is not the main pathway in humans on a Western diet. Recent evidence indicates paracellular absorption accounts for most phosphate uptake in humans.

Keywords:
Phosphategutintestinenephrologyparacellulartransport

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Area of Science:

  • Physiology
  • Nutritional Science
  • Gastroenterology

Background:

  • Phosphate is essential for numerous physiological processes.
  • Intestinal phosphate absorption is critical for maintaining phosphate homeostasis.
  • The predominant pathway for intestinal phosphate absorption in humans has been debated.

Purpose of the Study:

  • To review the evidence for transcellular intestinal phosphate absorption.
  • To evaluate the role of transcellular versus paracellular pathways in phosphate absorption in humans consuming a Western diet.
  • To highlight the current understanding of the primary mechanism of intestinal phosphate absorption.

Main Methods:

  • Literature review of existing studies on intestinal phosphate transport.
  • Analysis of physiological data related to phosphate absorption.
  • Synthesis of evidence supporting different absorption pathways.

Main Results:

  • The transcellular pathway is argued to be less significant in humans on a Western diet.
  • Recent evidence strongly supports the paracellular pathway as the predominant route for intestinal phosphate absorption.
  • Dietary factors in a Western diet may influence the dominant absorption mechanism.

Conclusions:

  • Paracellular intestinal phosphate absorption is the major pathway in humans.
  • Understanding the primary absorption mechanism is crucial for managing phosphate balance and related health conditions.
  • Further research into dietary influences on phosphate absorption is warranted.