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Updated: Jan 29, 2026

A Method for Islet Transplantation to the Omentum in Mouse
Published on: January 7, 2019
Bone tissue engineering in the greater omentum is enhanced by a periosteal transplant in a miniature pig model
Hendrik Naujokat1, Maximilian Lipp1, Yahya Açil1
1Department of Oral & Maxillofacial Surgery, University Hospital of Schleswig-Holstein, Campus Kiel, Arnold-Heller-Straße 3, 24105 Kiel, Germany.
Aim:
Reconstruction of bone defects with autologous grafts has certain disadvantages. The aim of this study is to introduce a new type of living bioreactor for engineering of bone flaps and to evaluate the effect of different barrier membranes.
Materials & Methods:
Scaffolds loaded with bone morphogenetic proteins and bone marrow aspirate wrapped with either a collagen membrane or a periosteal flap were implanted in the greater omentum of miniature pigs.
Results:
Both histological and radiographic evaluation showed proven bone formation and increased density after 8 and 16 weeks, with an enhanced effect of the periosteal transplant.
Conclusion:
The greater omentum is a suitable bioreactor for bone tissue engineering. Endocultivation is both an innovative and promising approach in regenerative medicine.
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