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Published on: February 4, 2017
64Cu-based Radiopharmaceuticals in Molecular Imaging
Yeye Zhou1, Jihui Li1, Xin Xu1
11 Department of Nuclear Medicine, The First Affiliated Hospital of Soochow University, Suzhou, China.
Abstract:
Copper-64 (T1/2 = 12.7 hours; β+: 19%, β-: 38%) has a unique decay profile and can be used for positron emission tomography imaging and radionuclide therapy. The well-established coordination chemistry of copper allows for its reaction with different types of chelator systems. It can be linked to antibodies, proteins, peptides, and other biologically relevant small molecules. Two potential ways to produce copper-64 radioisotopes concern the use of the cyclotron or the reactor. This review summarized several commonly used biomarkers of copper-64 radionuclide.
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