Effect of neuropeptides and monoamines on lymphocyte activation

Neuropeptides and monoamines have been found in tissues where immune reactions are initiated such as the skin, gut, and respiratory tract, and in these tissues neuropeptides and monoamines might be involved in the regulation of lymphocyte activation. Studies both in in vitro and in vivo showing that various neuropeptides and monoamines may influence reactions such as T lymphocyte proliferation, B lymphocyte proliferation, and antibody synthesis, lymphocyte migration, and cytotoxicity will be reviewed.