Related Experiment Video

Updated: Jan 29, 2026

Induction and Analysis of Epithelial to Mesenchymal Transition
10:37

Induction and Analysis of Epithelial to Mesenchymal Transition

Published on: August 27, 2013

36.5K

OLFM4 Inhibits Epithelial-Mesenchymal Transition and Metastatic Potential of Cervical Cancer Cells

Juan Li1, Chunyan Liu2, Dawei Li3

  • 1Department of Pathology, Qianfoshan Hospital Affiliated with Shandong University, Jinan, Shandong, P.R. China.

Oncology Research
|February 16, 2019
PubMed

Insights

OlfM4 (Olfactomedin 4) acts as a tumor suppressor in cervical cancer. Its reduced expression promotes metastasis, while its restoration inhibits cancer cell migration and invasion via the mTOR pathway.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Metastasis Research

Background:

  • Olfactomedin 4 (OLFM4) is implicated in tumor initiation and progression.
  • The role of OLFM4 in cervical cancer metastasis remains to be fully elucidated.

Purpose of the Study:

  • To investigate the function of OLFM4 in metastatic cervical cancer.
  • To identify the molecular mechanisms underlying OLFM4's role in cervical cancer progression.

Main Methods:

  • Analysis of OLFM4 expression in metastatic cervical cancer tissues.
  • Overexpression of OLFM4 in human cervical cancer cell lines.
  • Assessment of cell migration and invasion.
  • Investigation of the mTOR signaling pathway and its interaction with OLFM4.

Main Results:

  • OLFM4 expression is significantly decreased in metastatic cervical cancer.
  • Overexpression of OLFM4 suppresses epithelial-mesenchymal transition (EMT), migration, and invasion.
  • OLFM4 augmentation interferes with the mTOR signaling pathway.
  • Activation of mTOR signaling by phosphatidic acid (PA) partially reverses the inhibitory effects of OLFM4.

Conclusions:

  • OLFM4 functions as a tumor suppressor in cervical cancer.
  • OLFM4 inhibits cervical cancer cell metastasis by regulating the mTOR signaling pathway.

More Related Videos

Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells11:42

Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells

Published on: April 7, 2017

9.8K
Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells06:54

Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells

Published on: October 27, 2020

14.3K

Related Concept Videos

Phase Transitions02:31

Phase Transitions

Whether solid, liquid, or gas, a substance's state depends on the order and arrangement of its particles (atoms, molecules, or ions). Particles in the solid pack closely together, generally in a pattern. The particles vibrate about their fixed positions but do not move or squeeze past their neighbors. In liquids, although the particles are closely spaced, they are randomly arranged. The position of the particles are not fixed—that is, they are free to move past their neighbors to...
23.1K
Cell Potential and Free Energy02:58

Cell Potential and Free Energy

Thermodynamics of a Redox Reaction
Thermodynamics is the branch of physics dealing with the relationship between heat and other forms of energy. In an electrochemical cell, chemical energy is converted into electrical energy.
Thus, a link can be predicted between cell potential, free energy change, and the equilibrium constant for the reaction. Cell potential can also be measured as the oxidant or the reducing strength, and similar acid-base strength measures are reflected in equilibrium...
46.4K
Feedback Inhibition00:46

Feedback Inhibition

Biochemical reactions are occurring constantly in cells, converting starting substances to different products, usually with the help of enzymes that speed the reactions. Without enzymes, it would take far too long for most reactions to occur to be useful to the cell!
57.1K
Properties of Transition Metals02:58

Properties of Transition Metals

Transition metals are defined as those elements that have partially filled d orbitals. As shown in Figure 1, the d-block elements in groups 3–12 are transition elements. The f-block elements, also called inner transition metals (the lanthanides and actinides), also meet this criterion because the d orbital is partially occupied before the f orbitals.
29.7K
Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
5.6K
Cooperative Allosteric Transitions01:58

Cooperative Allosteric Transitions

Cooperative allosteric transitions can occur in multimeric proteins, where each subunit of the protein has its own ligand-binding site. When a ligand binds to any of these subunits, it triggers a conformational change that affects the binding sites in the other subunits; this can change the affinity of the other sites for their respective ligands. The ability of the protein to change the shape of its binding site is attributed to the presence of a mix of flexible and stable segments in the...
8.7K