Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure01:16

Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure

612
Oxygen therapy has emerged as a significant tool in enhancing the quality of life for patients suffering from pulmonary arterial hypertension (PAH). While this therapy has principally been studied on patients with significant hypoxemia, this therapeutic approach helps prevent potential organ damage and can be administered in the comfort of one's home.
Oxygen therapy is vital in increasing and maintaining blood oxygen levels in PAH patients. As a result, it aids in reducing fatigue,...
612
Long-term Depression01:05

Long-term Depression

33.2K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
33.2K
Gene Therapy00:59

Gene Therapy

27.6K
Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
27.6K
Oxygen Transport in the Blood01:27

Oxygen Transport in the Blood

6.5K
Hemoglobin (Hb) is a crucial molecule in the human body, consisting of four polypeptide chains, each bound to an iron-containing heme group. This unique structure enables hemoglobin to bind to oxygen, with each molecule capable of combining with four molecules of oxygen, leading to rapid and reversible oxygen loading. When fully loaded with oxygen, it is called oxyhemoglobin, while hemoglobin that has released oxygen is called reduced hemoglobin or deoxyhemoglobin. As hemoglobin binds oxygen,...
6.5K
Oxygen Delivering System II: Venturi Mask and Transtracheal Oxygen01:16

Oxygen Delivering System II: Venturi Mask and Transtracheal Oxygen

2.2K
Oxygen therapy is a pivotal aspect of medical care, particularly for patients with respiratory ailments. Two prominent oxygen-delivering systems include the Venturi mask and the transtracheal oxygen catheter.
Venturi Mask
The Venturi mask, named after the Venturi effect, is designed to deliver precise oxygen concentrations. It consists of a large tube with an oxygen inlet that narrows down, causing a pressure drop that pulls air in through adjustable side ports. The mask is a lightweight,...
2.2K
Regional Terms01:12

Regional Terms

15.4K
Regional terms describe anatomy by dividing the body parts into different regions that contain structures involved in contributing similar functions. Using these terms helps increase the accurate description and identification of the particular region of interest or region affected by the disease.
Primarily, the human body has two major regions, the axial and appendicular regions. The axial region comprises regions from the head to the abdomen and makes up the central body axis. In contrast,...
15.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Timely management of COPD exacerbations is associated with limited acute deterioration and early recovery: a prospective observational study.

Respiratory research·2026
Same author

Symptom-based rehabilitation in people with post-COVID-19 condition (RELOAD study): a randomised controlled trial.

BMJ open respiratory research·2026
Same author

Lower airway dysbiosis fuels NETosis in nontuberculous mycobacterial bronchiectasis: rethinking the microbiome-host axis.

American journal of respiratory and critical care medicine·2026
Same author

The Montafon Proposal: New Insights and Emerging Concepts in Pulmonary Rehabilitation.

Respiration; international review of thoracic diseases·2026
Same author

COPD Exacerbation Recognition Tool: Translation, Linguistic, and Cross-Cultural Validation.

Chronic obstructive pulmonary diseases (Miami, Fla.)·2026
Same author

Pulmonary rehabilitation in adults with asthma.

Current opinion in pulmonary medicine·2026

Related Experiment Video

Updated: Jan 29, 2026

Author Spotlight: Extended Oxygen Consumption Measurement in Retinal Pigment Epithelium Using Resipher
08:09

Author Spotlight: Extended Oxygen Consumption Measurement in Retinal Pigment Epithelium Using Resipher

Published on: August 16, 2024

5.5K

Long-Term Oxygen Therapy.

Andreas Rembert Koczulla1, Tessa Schneeberger, Inga Jarosch

  • 1Institute for Pulmonary Rehabilitation Research, Schoen Klinik Berchtesgadener Land, Schoenau am Koenigssee; Philipps University Marburg (Schoenau site), German Center for Lung Research (DZL), Marburg; Department for Prevention, Rehabilitation, and Sports Medicine, Technical University Munich (TUM), Munich, Germany.

Deutsches Arzteblatt International
|February 16, 2019
PubMed
Summary

Long-term oxygen therapy (LTOT) improves survival in hypoxemic patients with COPD, but more data are needed for other conditions. LTOT is recommended for strict indications, with potential risks like burns.

More Related Videos

Production and Detection of Reactive Oxygen Species ROS in Cancers
07:17

Production and Detection of Reactive Oxygen Species ROS in Cancers

Published on: November 21, 2011

71.0K
Cerebral Blood Oxygenation Measurement Based on Oxygen-dependent Quenching of Phosphorescence
08:58

Cerebral Blood Oxygenation Measurement Based on Oxygen-dependent Quenching of Phosphorescence

Published on: May 4, 2011

15.2K

Related Experiment Videos

Last Updated: Jan 29, 2026

Author Spotlight: Extended Oxygen Consumption Measurement in Retinal Pigment Epithelium Using Resipher
08:09

Author Spotlight: Extended Oxygen Consumption Measurement in Retinal Pigment Epithelium Using Resipher

Published on: August 16, 2024

5.5K
Production and Detection of Reactive Oxygen Species ROS in Cancers
07:17

Production and Detection of Reactive Oxygen Species ROS in Cancers

Published on: November 21, 2011

71.0K
Cerebral Blood Oxygenation Measurement Based on Oxygen-dependent Quenching of Phosphorescence
08:58

Cerebral Blood Oxygenation Measurement Based on Oxygen-dependent Quenching of Phosphorescence

Published on: May 4, 2011

15.2K

Area of Science:

  • Pulmonary Medicine
  • Respiratory Therapy

Background:

  • Long-term oxygen therapy (LTOT) is a standard treatment for chronic hypoxemia, primarily supported by early 1980s trials in COPD patients.
  • Limited robust data exist for LTOT efficacy in other hypoxemic conditions.

Purpose of the Study:

  • To review the current evidence and guidelines for long-term oxygen therapy (LTOT) in hypoxemic patients.
  • To highlight the need for updated research on LTOT's impact on patient-relevant outcomes.

Main Methods:

  • A selective PubMed search was conducted to identify pertinent publications.
  • The review synthesizes findings from existing literature and clinical guidelines.

Main Results:

  • Current guidelines recommend LTOT for 15-16 hours/day (or 24 hours/day) for hypoxemic patients (PaO2 ≤ 55 mm Hg), showing reduced mortality (33% vs. 55%).
  • Short-term oxygen improves saturation and physical performance (6-minute walking test +37m).
  • LTOT is not supported for normoxemic patients and carries risks like burns.

Conclusions:

  • Further robust data on LTOT's impact on quality of life, performance, and mortality are needed.
  • Existing German guidelines for oxygen therapy require updating.