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Cancer cells in the tumor core exhibit spatially coordinated migration patterns
Ralitza Staneva1,2, Fatima El Marjou3, Jorge Barbazan3
1Institut Curie, PSL Research University, CNRS, UMR 144 - Cell Biology and Cancer, 75005 Paris, France ralitza.staneva@curie.fr andrew.clark@curie.fr.
Journal of Cell Science
|February 16, 2019
Summary
Cancer cells within the tumor core are highly dynamic, exhibiting coordinated movements that drive tissue dynamics and contribute to metastasis. These findings reveal new insights into cancer cell migration and tumor progression.
Area of Science:
- Oncology
- Cell Biology
- Biophysics
Background:
- Metastasis involves cancer cells exiting the primary tumor.
- Research often focuses on the tumor invasive front, neglecting the tumor core.
- Cancer cells from the tumor core can also contribute to metastasis.
Purpose of the Study:
- To investigate cell motility within the tumor core.
- To understand the dynamics of cancer cells in the tumor core.
Main Methods:
- Real-time imaging of tumor explants using long-term two-photon microscopy.
- Utilized pharmacological inhibitors to probe migration mechanisms.
- Analyzed cell migration speed and correlation length.
Main Results:
- Cancer cells in the tumor core display dynamic and correlated migration patterns, forming 'currents'.
- Cell migration is actin cytoskeleton-dependent.
- Observed a relationship between migration speed and correlation length, indicating proximity to a jamming transition.
Conclusions:
- Cancer cell dynamics in the tumor core are significant for metastasis.
- Findings offer new perspectives on cancer cell migratory properties.
- Suggests potential for novel therapeutic strategies targeting tumor core dynamics.
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