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Co-localization of Cell Lineage Markers and the Tomato Signal
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BCR-dependent lineage plasticity in mature B cells
Robin Graf1, Jane Seagal2, Kevin L Otipoby2
1Immune Regulation and Cancer, Max Delbrück Center for Molecular Medicine in the Helmholtz Association, 13125 Berlin, Germany. robin.graf@mdc-berlin.de klaus.rajewsky@mdc-berlin.de.
Science (New York, N.Y.)
|February 16, 2019
Summary
B2 cells can transform into B1 cells, a type of innate immune cell, when their B cell antigen receptor (BCR) recognizes self antigens. This discovery reveals a new differentiation pathway for B cells.
Area of Science:
- Immunology
- Cell Biology
- Molecular Biology
Background:
- B2 cells perform antibody responses, while B1 cells are linked to innate immunity and recognize common pathogens and self antigens.
- The specific role of B cell antigen receptor (BCR) in directing B1 cell differentiation remains incompletely understood.
Purpose of the Study:
- To investigate how BCR specificity influences B1 cell differentiation.
- To determine if B2 cells possess the potential to differentiate into B1 cells.
Main Methods:
- Developed a transgenic system for inducible and programmed alteration of BCR specificity in B cells.
- Induced changes in BCR specificity in mature B2 cells.
Main Results:
- Mature B2 cells successfully differentiated into B1 cells after acquiring a self-reactive BCR characteristic of B1 cells.
- This differentiation process involved a phase of proliferative expansion.
- B1 cell differentiation was driven by BCR-mediated self-reactivity.
Conclusions:
- B2 cells have the latent capacity to differentiate into B1 cells, expanding their known differentiation potential.
- BCR-mediated self-reactivity is a key instructional signal for B1 cell differentiation, independent of prior B1-lineage commitment.
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