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Updated: Jan 29, 2026

Elastic Staining on Paraffin-embedded Slides of pT3N0M0 Gastric Cancer Tissue
Published on: May 1, 2019
[A Case of Advanced Cardia Gastric Cancer with Pernicious Anemia]
Takashi Katsumori1, Hisami Ohshima, Hiromitsu Hamaguchi
1Dept. of Surgery, Arao Municipal Hospital.
Insights
This case study highlights a 70-year-old male diagnosed with advanced gastric cancer and pernicious anemia. Successful treatment involved vitamin B12, gastrectomy, and chemotherapy, leading to a 5-year recurrence-free survival.
Area of Science:
- Gastroenterology
- Oncology
- Hematology
Background:
- Gastric cancer can present with nonspecific symptoms like anemia.
- Pernicious anemia, an autoimmune condition, is characterized by macrocytic anemia and intrinsic factor antibodies.
- Co-occurrence of gastric cancer and pernicious anemia requires careful diagnostic and therapeutic management.
Abstract:
A 70s male was referred to our hospital with anemia that was detected during a medical checkup. Upper gastrointestinal endoscopy showed advanced cardia gastric cancer. A diagnosis of pernicious anemia was made due to the macrocytic hyperchromic anemia and detection of intrinsic factor antibody. A CT scan showed fundic wall thickening and regional lymph node metastasis. After anemia improved following vitamin B12 injection, total gastrectomy with lymphadenectomy was performed. The histopathological findings showed adenocarcinoma(tub1>tub2), Type2 , pT3(SS), pN1(2/24), Stage ⅡB, INF b, ly1, v2, PM0, DM0, EW(+), pR1. He was administered systematic chemotherapy using S-1 for one year after surgery and has been followed up without recurrence for 5 years.
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