Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Gap Junctions01:37

Gap Junctions

57.1K
Multicellular organisms employ a variety of ways for cells to communicate with each other. Gap junctions are specialized proteins that form pores between neighboring cells in animals, connecting the cytoplasm between the two, and allowing for the exchange of molecules and ions. They are found in a wide range of invertebrate and vertebrate species, mediate numerous functions including cell differentiation and development, and are associated with numerous human diseases, including cardiac and...
57.1K
Gap Junctions01:27

Gap Junctions

9.5K
The cytoplasm of adjacent animal cells can exchange small molecules, ions, and secondary messengers via the communication channels which form the gap junctions. These junctions comprise a few hundred to thousands of molecular channels, each made of two halves, called the connexon hemichannel. A connexon is a hexamer of six transmembrane connexin proteins, which assemble radially, thus forming a pore or channel in the center. One connexon hemichannel docks with a corresponding connexon on the...
9.5K
Lattice Centering and Coordination Number02:33

Lattice Centering and Coordination Number

11.5K
The structure of a crystalline solid, whether a metal or not, is best described by considering its simplest repeating unit, which is referred to as its unit cell. The unit cell consists of lattice points that represent the locations of atoms or ions. The entire structure then consists of this unit cell repeating in three dimensions. The three different types of unit cells present in the cubic lattice are illustrated in Figure 1.
Types of Unit Cells
Imagine taking a large number of identical...
11.5K
Center of Gravity00:58

Center of Gravity

6.7K
The center of gravity (COG) of an object is the point where the object's total weight is considered to be concentrated. Knowing the location of the center of gravity is useful when predicting the behavior of a moving object or designing static structures. In a uniform gravitational field, the center of gravity is similar to the center of mass (COM); yet, these two points can be positioned differently. For example, the Moon's center of mass lies very close to its geometric center, but...
6.7K
Center of Gravity01:15

Center of Gravity

2.2K
The center of gravity is the point at which an object's weight appears to be concentrated and can be used to balance the object perfectly. This point is essential in mechanics as it provides information regarding a body's stability and moments of inertia. The center of gravity does not always have to fall within the shape or boundaries of the body; it may also lie outside the body in certain cases.
To determine its location, the principle of moments can be utilized by dividing the object into...
2.2K
Center of Mass00:59

Center of Mass

2.0K
The center of mass is the point at which the total mass of an object can be said to be concentrated. It is a fundamental principle in mechanics and physics that applies to all objects regardless of their shape or size. The center of gravity is the point at which an object’s weight appears to be concentrated and can be used to balance the object perfectly.
The knowledge of the center of mass can also help us to describe and predict the motion of objects. For example, when a ball is thrown...
2.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Long-Term Outcomes and Surgical Conversion After Immunotherapy in Microsatellite Instability-H Biliary Tract Cancers.

JCO precision oncology·2026
Same author

Acute Liver Failure in a Patient with Myasthenia Gravis.

Gastroenterology·2026
Same author

Non-invasive profiling of the tumour microenvironment with spatial ecotypes.

Nature·2026
Same author

Predictors of Immune Checkpoint Blockade Response in dMMR Colorectal Cancer Using an Integrated Immune-Enhanced Multi-Omics Platform.

Clinical cancer research : an official journal of the American Association for Cancer Research·2026
Same author

Inflammatory adenoma-like hepatocellular neoplasm in cirrhotic livers.

Histopathology·2026
Same author

Push pin induced artifact: A mimic of iron pill injury in gastrointestinal pathology.

Human pathology·2026

Related Experiment Video

Updated: Jan 29, 2026

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
05:47

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems

Published on: June 13, 2025

1.4K

Knowledge gaps in the appendix: a multi-institutional study from seven academic centers.

Christina A Arnold1, Rondell P Graham2, Dhanpat Jain3

  • 1Department of Pathology, The Ohio State University Wexner Medical Center, Columbus, OH, USA. Christina.Arnold@OSUMC.edu.

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
|February 16, 2019
PubMed
Summary
This summary is machine-generated.

Pathology consultations for appendix specimens reveal significant diagnostic discrepancies, particularly for low-grade appendiceal mucinous neoplasms. These findings highlight knowledge gaps and the need for improved diagnostic criteria in appendix pathology.

More Related Videos

A Knowledge Graph Approach to Elucidate the Role of Organellar Pathways in Disease via Biomedical Reports
07:35

A Knowledge Graph Approach to Elucidate the Role of Organellar Pathways in Disease via Biomedical Reports

Published on: October 13, 2023

2.1K
Author Spotlight: Exploring Dynamic Neural Changes Associated with Religious Chanting
05:05

Author Spotlight: Exploring Dynamic Neural Changes Associated with Religious Chanting

Published on: May 31, 2024

1.3K

Related Experiment Videos

Last Updated: Jan 29, 2026

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
05:47

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems

Published on: June 13, 2025

1.4K
A Knowledge Graph Approach to Elucidate the Role of Organellar Pathways in Disease via Biomedical Reports
07:35

A Knowledge Graph Approach to Elucidate the Role of Organellar Pathways in Disease via Biomedical Reports

Published on: October 13, 2023

2.1K
Author Spotlight: Exploring Dynamic Neural Changes Associated with Religious Chanting
05:05

Author Spotlight: Exploring Dynamic Neural Changes Associated with Religious Chanting

Published on: May 31, 2024

1.3K

Area of Science:

  • Gastrointestinal Pathology
  • Surgical Pathology
  • Oncologic Pathology

Background:

  • Appendix pathology presents unique diagnostic challenges due to uncommon specimen encounters.
  • Extramural consultations are frequently sought for complex appendiceal specimens.

Purpose of the Study:

  • To identify common knowledge gaps in appendix pathology through review of extramural consultations.
  • To analyze diagnostic discrepancies in appendiceal neoplasms, focusing on low-grade appendiceal mucinous neoplasms and goblet cell carcinoids.

Main Methods:

  • Retrospective review of 43 appendix resections submitted for extramural consultation across seven institutions (2016-2017).
  • Analysis of consultation themes, diagnostic disagreements, and reasons for discrepancies.

Main Results:

  • Low-grade appendiceal mucinous neoplasms (LAMN) and goblet cell carcinoid (GCC) related neoplasms constituted the majority of consults (44% and 19%, respectively).
  • Significant diagnostic disagreements were observed, with 53% of cases showing discrepancies between submitted and consultant diagnoses.
  • Major disagreements included downgrades from LAMN to serrated polyp or benign appendix, and upgrades to LAMN with high-risk features or mucinous adenocarcinoma.

Conclusions:

  • Substantial diagnostic variability exists in appendix pathology, especially for LAMN.
  • Consultation patterns indicate a need for clearer diagnostic criteria and consensus on staging and invasion assessment for appendiceal neoplasms.
  • Further studies are warranted to address these diagnostic challenges and improve patient care.