Author Correction: Predictable and precise template-free CRISPR editing of pathogenic variants

  • 0Computational and Systems Biology Program, Massachusetts Institute of Technology, Cambridge, MA, USA.

|

|

Summary

This summary is machine-generated.

Data processing errors in Fig. 3e and Extended Data Table 2 have been corrected. This ensures the accuracy of the presented scientific data for researchers.

Area Of Science

  • Data Science
  • Scientific Research Methodology

Background

  • Accurate data representation is crucial for scientific integrity.
  • Errors in data processing can impact the reliability of research findings.

Purpose Of The Study

  • To report and correct a data processing error affecting specific figures and tables.
  • To ensure the accuracy and reliability of the published scientific data.

Main Methods

  • Data processing pipeline review.
  • Identification and correction of a specific data processing error.
  • Online update of affected figures and tables.

Main Results

  • A data processing error in Fig. 3e has been identified and corrected.
  • A data processing error in Extended Data Table 2 has been identified and corrected.
  • Corrected versions of Fig. 3e and Extended Data Table 2 are now available online.

Conclusions

  • The integrity of the scientific data presented in the Article has been restored.
  • Researchers can now rely on the corrected Fig. 3e and Extended Data Table 2.
  • This highlights the importance of rigorous data validation in scientific publishing.

Related Concept Videos

Milgram's Obedience to Authority 02:20

7.3K

Obedience to authority is classically demonstrated in a more famous series of social psychology experiments performed by Stanley Milgram. He was a social psychology professor at Yale who was influenced by the trial of Adolf Eichmann, a Nazi war criminal. Eichmann’s defense for the atrocities he committed was that he was “just following orders.”

Milgram’s Experiments

Milgram (1963) wanted to test the validity of this defense, so he designed an experiment and...

CRISPR/Cas9 Genome Editing 01:28

1.8K

The CRISPR-Cas system serves as a bacterial defense mechanism against invading genetic elements such as viruses and plasmids, forming the foundation for its adaptation as a powerful genome-editing tool. Originally discovered in prokaryotes, this system has been repurposed to revolutionize genetic engineering across a wide range of organisms, including plants, animals, and humans. The core component, Cas9, is an endonuclease derived from Streptococcus pyogenes, capable of introducing...

CRISPR 01:59

57.8K

Genome editing technologies allow scientists to modify an organism’s DNA via the addition, removal, or rearrangement of genetic material at specific genomic locations. These types of techniques could potentially be used to cure genetic disorders such as hemophilia and sickle cell anemia. One popular and widely used DNA-editing research tool that could lead to safe and effective cures for genetic disorders is the CRISPR-Cas9 system. CRISPR-Cas9 stands for Clustered Regularly Interspaced...

Uncertainty in Measurement: Accuracy and Precision 03:37

100.9K

Scientists typically make repeated measurements of a quantity to ensure the quality of their findings and to evaluate both the precision and the accuracy of their results. Measurements are said to be precise if they yield very similar results when repeated in the same manner. A measurement is considered accurate if it yields a result that is very close to the true or the accepted value. Precise values agree with each other; accurate values agree with a true value. 

Suppose a quality...

CRISPR and crRNAs 02:53

19.1K

Bacteria and archaea are susceptible to viral infections just like eukaryotes; therefore, they have developed a unique adaptive immune system to protect themselves. Clustered regularly interspaced short palindromic repeats and CRISPR-associated proteins (CRISPR-Cas) are present in more than 45% of known bacteria and 90% of known archaea.
The CRISPR-Cas system stores a copy of foreign DNA in the host genome and uses it to identify the foreign DNA upon reinfection. CRISPR-Cas has three different...

RNA Editing 02:23

9.9K

RNA editing is a post-transcriptional modification where a precursor mRNA (pre-mRNA) nucleotide sequence is changed by base insertion, deletion, or modification. The extent of RNA editing varies from a few hundred bases, in mitochondrial DNA of trypanosomes, to a just single base, in nuclear genes of mammals. Even a single base change in the pre-mRNA can convert a codon for one amino acid into the codon for another amino acid or a stop codon. This type of re-coding can significantly affect the...