Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The deafferented visual cortex and interhemispheric relationships: a physiological approach.

U Yinon1, M Podell

  • 1Maurice and Gabriela Goldschleger Eye Research Institute, Tel-Aviv University Sackler Faculty of Medicine, Chaim Sheba Medical Center, Tel Hashomer, Israel.

Metabolic, Pediatric, and Systemic Ophthalmology (New York, N.Y. : 1985)
|January 1, 1988
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

2015 ACVIM Small Animal Consensus Statement on Seizure Management in Dogs.

Journal of veterinary internal medicine·2016
Same author

Neuronal loss in FIV-MD infected cats.

Journal of neuro-AIDS·2006
Same author

Columnar organization of the mammalian visual cortex and its vulnerability following lesion in adult cats.

Brain injury·2005
Same author

Functional organization of columns in damaged visual cortex of adult cats.

Journal of basic and clinical physiology and pharmacology·2003
Same author

Pharmacokinetics and toxicity of bromide following high-dose oral potassium bromide administration in healthy Beagles.

Journal of veterinary pharmacology and therapeutics·2002
Same author

Intrinsic thermal resistance of the canine brain.

Neuroscience·2002
Same journal

Treatment of scleral melt associated with uveal prolapse by pericardium grafting in Wegener's granulomatosis.

Metabolic, pediatric, and systemic ophthalmology (New York, N.Y. : 1985)·2002
Same journal

Optic nerve compression by extramedullary hematopoietic tissue in a patient suffering from beta-thalassemia intermedia.

Metabolic, pediatric, and systemic ophthalmology (New York, N.Y. : 1985)·2002
Same journal

Processing of animated contours by single cells in visual cortex area 18 of the cat.

Metabolic, pediatric, and systemic ophthalmology (New York, N.Y. : 1985)·2002
Same journal

Fluorescein angiography and indocyanine green videoangiography in the iris of pseudoexfoliation syndrome.

Metabolic, pediatric, and systemic ophthalmology (New York, N.Y. : 1985)·2001
Same journal

Anterior chamber hemorrhage during cataract surgery in Lowe syndrome.

Metabolic, pediatric, and systemic ophthalmology (New York, N.Y. : 1985)·2001
Same journal

A review of the role of visual problems in reading disabilities.

Metabolic, pediatric, and systemic ophthalmology (New York, N.Y. : 1985)·2001
See all related articles

Unilateral optic tract section in cats inactivates the callosal pathway, disrupting visual information transfer between hemispheres. Early monocular deprivation exacerbates these effects, highlighting the importance of simultaneous visual input for callosal function.

Area of Science:

  • Neuroscience
  • Visual System Research
  • Comparative Neurology

Background:

  • Asymmetrical visual system activation can result from unilateral optic tract section (OTX).
  • Monocular deprivation (MD) during critical developmental periods can alter visual system plasticity.
  • Understanding callosal pathway function is crucial for visual information processing.

Purpose of the Study:

  • To investigate the effects of unilateral optic tract section (OTX) on visual system activation in adult cats.
  • To examine how early-onset monocular deprivation (MD-OTX) influences visual processing after OTX.
  • To determine the impact of asymmetrical geniculo-cortical input on the callosal pathway.

Main Methods:

  • Extracellular single-unit recordings in visual cortical areas (17, 18) of adult cats.

Related Experiment Videos

  • Comparison between OTX, MD-OTX, MD, and normal control groups.
  • Analysis of contralateral callosal input and visual responsiveness, orientation, and direction selectivity.

    • Main Results:

    • Contralateral callosal input was virtually undetectable in isolated hemispheres of OTX and MD-OTX cats.
    • Intact hemispheres showed largely unaffected binocularity, with minor changes near the vertical meridian.
    • MD-OTX cats with early deprivation showed increased deprived eye responsiveness; visual responsiveness and selectivity were reduced in OTX/MD-OTX groups.

    Conclusions:

    • Asymmetrical geniculo-cortical input leads to bidirectional inactivation of the callosal pathway for visual information transfer.
    • Callosal pathway activation depends on simultaneous, reciprocal interactions between the two cerebral hemispheres.
    • Findings suggest a critical role for balanced visual input in maintaining interhemispheric communication in the visual cortex.