Related Experiment Video

Updated: Jan 29, 2026

Identification of Fatty Acids in Bacillus cereus
08:41

Identification of Fatty Acids in Bacillus cereus

Published on: December 5, 2016

10.1K

The Most Expensive Drug in the World: To Continue or Discontinue, That Is the Question

Rola Khedraki1, Zorawar Noor1, James Rick1

  • 1is a resident physician and is chief resident physician, both in internal medicine at the University of California, Irvine. is a staff physician at the Long Beach Healthcare System in California.

Federal Practitioner : for the Health Care Professionals of the VA, Dod, and PHS
|February 16, 2019
PubMed

Insights

Personalized treatment for atypical hemolytic uremic syndrome (aHUS) may improve patient outcomes. Considering genetic and medical factors can guide therapy for this rare, lifelong condition.

Area of Science:

  • Nephrology
  • Genetics
  • Pharmacogenomics

Background:

  • Atypical hemolytic uremic syndrome (aHUS) is a rare, life-threatening thrombotic microangiopathy.
  • Patients often require long-term, costly treatment with increased infection risks.
  • Current management strategies may not fully address individual patient variability.

Purpose of the Study:

  • To explore the potential benefits of personalized treatment approaches for aHUS.
  • To evaluate the impact of genetic and medical history on therapeutic strategies.
  • To identify optimal management for patients with aHUS.

Main Methods:

  • Review of existing literature on aHUS treatment.
  • Analysis of genetic and clinical data in aHUS patient cohorts.
  • Comparative effectiveness research of tailored vs. standard therapy.

Main Results:

  • Genetic profiling can identify specific aHUS subtypes.
  • Medical history provides crucial context for treatment selection.
  • Personalized approaches show promise in optimizing aHUS management.

Conclusions:

  • Tailoring aHUS therapy based on individual genetic and medical profiles is a promising strategy.
  • Personalized medicine may mitigate risks associated with lifelong treatment.
  • Further research is warranted to validate these findings in clinical practice.

More Related Videos

Preparation of Synaptic Plasma Membrane and Postsynaptic Density Proteins Using a Discontinuous Sucrose Gradient08:06

Preparation of Synaptic Plasma Membrane and Postsynaptic Density Proteins Using a Discontinuous Sucrose Gradient

Published on: September 3, 2014

32.0K
Studying the Hypothalamic Insulin Signal to Peripheral Glucose Intolerance with a Continuous Drug Infusion System into the Mouse Brain08:32

Studying the Hypothalamic Insulin Signal to Peripheral Glucose Intolerance with a Continuous Drug Infusion System into the Mouse Brain

Published on: January 4, 2018

10.9K

Related Concept Videos

Limits with Oscillating Discontinuities01:19

Limits with Oscillating Discontinuities

An oscillating discontinuity is a type of discontinuity in which a function’s values fluctuate infinitely often as the input approaches a particular point. Unlike jump discontinuities, where the function suddenly shifts between two values, or infinite discontinuities, where the function diverges without bound, an oscillating discontinuity arises from rapid back-and-forth variation. Because the function never stabilizes toward a single value, no finite limit exists at that point.One of the...
456
Improper Integrals: Discontinuous Integrands01:28

Improper Integrals: Discontinuous Integrands

Evaluating Areas Under Curves with DiscontinuitiesA definite integral is considered improper when the integrand is discontinuous at one of the limits of integration. This occurs when the function is undefined or becomes infinite at an endpoint, making the corresponding region under the curve unbounded. Such behavior is commonly associated with vertical asymptotes at the boundary of the interval. To properly define and evaluate these integrals, a limiting process is used to determine whether a...
52
Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy01:26

Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy

Continuous Renal Replacement Therapy (CRRT) is an essential intervention for patients experiencing severe kidney dysfunction. This therapy offers a continuous mechanism for removing fluids and toxins from the bloodstream, leveraging the patient’s blood pressure to facilitate filtration through a specialized filter. This method contrasts with intermittent dialysis, providing a gentler and more consistent removal of waste products and excess fluid, which is particularly beneficial in...
205
Continuing Care01:25

Continuing Care

Continuing care describes the variety of health, personal, and social services provided over a prolonged period. The need for continuing care is increasing because people are living longer. Many people do not have families or others to care for them. Continuing care is mainly for patients who are disabled, functionally dependent, or suffering from a terminal disease. It is available within institutional settings or in homes. Examples include nursing centers or facilities, assisted living,...
1.9K
Continuity of a Function01:23

Continuity of a Function

A function is continuous at a point a if three conditions are met: the function is defined at a, the limit of the function as x approaches a exists, and this limit equals the function’s value. Mathematically, this is written asThis definition ensures the graph of the function does not exhibit any breaks, holes, or jumps at that point. Discontinuities occur when any of these conditions fail. A removable discontinuity exists when the two-sided limit exists but the function is either...
237
Continuity Equation01:28

Continuity Equation

The continuity equation asserts that the mass flow rate must remain constant for a steady flow of an incompressible fluid within a confined system. This principle applies to systems where fluid passes through varying cross-sectional areas, such as nozzles, syringes, and pipes.
The mass flow rate is expressed as:
3.3K