Related Experiment Video

Updated: Jan 29, 2026

Patient-derived Orthotopic Xenograft Models for Human Urothelial Cell Carcinoma and Colorectal Cancer Tumor Growth and Spontaneous Metastasis
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Immune Checkpoint Inhibitors for Urothelial Cancer: An Update on New Therapies

Nemer El-Mouallem1, Asit K Paul1

  • 1is a Fellow in Hematology and Medical Oncology at the Hunter Holmes McGuire VA Medical Center in Richmond, Virginia, and a Fellow in the Division of Hematology, Oncology, and Palliative Care at Virginia Commonwealth University (VCU) in Richmond. is Assistant Clinical Professor in the Division of Hematology, Oncology, and Palliative Care at Massey Cancer Center at VCU Medical Center.

Federal Practitioner : for the Health Care Professionals of the VA, Dod, and PHS
|February 16, 2019
PubMed

Insights

Ongoing clinical trials are exploring immune checkpoint inhibitors for advanced bladder cancer. These therapies are being tested alone and in combination with other treatments to improve patient outcomes.

Area of Science:

  • Oncology
  • Immunotherapy

Background:

  • Advanced bladder cancer presents significant treatment challenges.
  • Immune checkpoint inhibitors have emerged as a promising therapeutic strategy.

Purpose of the Study:

  • To summarize the ongoing clinical trials evaluating immune checkpoint inhibitors in advanced bladder cancer.
  • To explore various combination strategies involving these inhibitors.

Main Methods:

  • Review of ongoing clinical trials.
  • Analysis of combination therapies including cytotoxic, targeted, and radiation treatments.
  • Evaluation of combinations with other immune checkpoint inhibitors.

Main Results:

  • Immune checkpoint inhibitors are being investigated in diverse therapeutic regimens.
  • Combination strategies aim to enhance efficacy in advanced bladder cancer.

Conclusions:

  • The landscape of advanced bladder cancer treatment is evolving with immunotherapy.
  • Further research is crucial to establish optimal combination strategies and improve patient survival.

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