Feeding difficulties in infants with unrepaired cleft lip and palate and HIV-exposure

Erantia E Visser1, Esedra E Krüger1, Aletta Margaretha1

  • 1Department of Speech-Language Pathology and Audiology, Faculty of Humanities, University of Pretoria Private Bag X20, Hatfield 0028.

African Health Sciences
|February 16, 2019
PubMed

Insights

Infants with cleft lip and palate and HIV exposure showed higher rates of oropharyngeal dysphagia compared to those without HIV exposure. This suggests potential neurological involvement impacting feeding in this vulnerable population.

Area of Science:

  • Pediatric Feeding Disorders
  • Neonatal Health
  • Cleft Lip and Palate Research

Background:

  • Limited data exists on feeding characteristics of infants with unrepaired cleft lip and palate (CLP) who are exposed to HIV.
  • Understanding these feeding patterns is crucial for early intervention and improved outcomes.

Purpose of the Study:

  • To compare feeding characteristics in infants with unrepaired CLP and HIV exposure versus infants with unrepaired CLP only.
  • To identify potential differences in oral feeding skills and dysphagia risk.

Main Methods:

  • A comparative study utilized the Neonatal Feeding Assessment Scale.
  • Twelve HIV-exposed infants with unrepaired CLP were compared to 13 infants with unrepaired CLP.
  • Participants were matched for cleft type and obturator use; age, birth weight, and gestation were similar.

Main Results:

  • 75% of HIV-exposed infants showed likelihood of oropharyngeal dysphagia, versus 15.38% in the control group.
  • HIV-exposed infants exhibited symptoms suggestive of neurological involvement beyond structural CLP issues.
  • Feeding difficulties were exacerbated in the HIV-exposed group.

Conclusions:

  • HIV-exposed infants with unrepaired CLP present distinct symptoms of oropharyngeal dysphagia.
  • Further research with diverse measurement tools is recommended to validate these findings.
  • Early identification of dysphagia in this population is critical.
Abstract

Related Concept Videos

Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
283
Enteral Nutrition I: Orogastric and Nasogastric Feeding01:26

Enteral Nutrition I: Orogastric and Nasogastric Feeding

Enteral nutrition delivers nutrients directly to the stomach or small intestine through a tube. This method is appropriate for patients who cannot eat but still have a functioning digestive system. It is also beneficial for individuals with swallowing difficulties, anorexia, malabsorption, or those who have undergone gastrointestinal (GI) surgery.
Orogastric (OG) and nasogastric (NG) feeding are two standard methods used for enteral nutrition. Enteral nutrition is often preferred over...
1.4K
Enteral Nutrition II: Nasointestinal and Gastrostomy Feeding01:15

Enteral Nutrition II: Nasointestinal and Gastrostomy Feeding

Enteral nutrition encompasses various methods of delivering nutrition directly to the gastrointestinal (GI) tract, bypassing traditional oral intake. It is particularly beneficial for patients who cannot eat by mouth but have a functioning digestive system. Key methods include nasointestinal feeding, gastrostomy, and jejunostomy, each suited to different clinical scenarios based on the patient's needs and condition.
Nasointestinal Feeding
Nasointestinal feeding involves placing a tube...
957
The Synapse02:47

The Synapse

Neurons communicate with one another by passing on their electrical signals to other neurons. A synapse is the location where two neurons meet to exchange signals. At the synapse, the neuron that sends the signal is called the presynaptic cell, while the neuron that receives the message is called the postsynaptic cell. Note that most neurons can be both presynaptic and postsynaptic, as they both transmit and receive information.
133.0K
Fixing Double-strand Breaks02:04

Fixing Double-strand Breaks

The double-stranded structure of DNA has two major advantages. First, it serves as a safe repository of genetic information where one strand serves as the back-up in case the other strand is damaged. Second, the double-helical structure can be wrapped around proteins called histones to form nucleosomes, which can then be tightly wound to form chromosomes. This way, DNA chains up to 2 inches long can be contained within microscopic structures in a cell. A double-stranded break not only damages...
14.6K
Synaptic Signaling01:12

Synaptic Signaling

Neurons communicate at synapses, or junctions, to excite or inhibit the activity of other neurons or target cells, such as muscles. Synapses may be chemical or electrical.
79.3K