Related Experiment Video For Causality
Updated: Jan 29, 2026

Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro
Published on: January 31, 2022
Novel Approaches to Causality Adjudication in Drug-Induced Liver Disease
Hans L Tillmann1, Huiman X Barnhart2, Jose Serrano3
1Division of Gastroenterology, East Carolina University, Greenville, NC.
Purpose Of Review:
Drug induced liver injury (DILI) is a complex diagnosis dominantly based of exclusion.
Recent Findings:
Currently available causality assessment instruments are considered to be suboptimal. Expert opinion appears to be best method to adjudicate causality, but is impractical to implement on a wide scale basis. Thus, new approaches are needed, for example improving the specificity of current scoring systems. A further option would be to develop a system that utilizes computer-based scoring - which would reduce human error. Additionally, it would be ideal to have available drug specific scoring systems, based on drugs' characteristic "phenotypes" (presentation and pattern of injury). Eventually, a validated system could be integrated within the electronic health information system.
Summary:
This review highlights an avenue to an improved Causality Assessment Tool.
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