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Liraglutide - Indian Experience.

Majumder Anirban1, Roy Chaudhri Soumyabrata1, Sanyal Debmalya1

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Indian Journal of Endocrinology and Metabolism
|February 16, 2019
PubMed
Summary

Liraglutide shows superior real-world effectiveness in Indian patients with type 2 diabetes, achieving greater HbA1c reduction and weight loss compared to Western trials. Adverse events remain similar.

Keywords:
EffectivenessIndialiraglutideliterature reviewreal-worldtype 2 diabetesweight

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Area of Science:

  • Endocrinology
  • Metabolic Disorders
  • Pharmacology

Background:

  • Type 2 diabetes mellitus (T2DM) poses a significant global health challenge.
  • Liraglutide is an established pharmacotherapy for T2DM management.
  • Real-world data on liraglutide's effectiveness in diverse populations, particularly India, is crucial.

Purpose of the Study:

  • To review and synthesize evidence on the real-world clinical effectiveness of liraglutide in Indian patients with T2DM.
  • To compare the outcomes of liraglutide therapy in Indian observational studies with results from the Liraglutide Effect and Action in Diabetes (LEAD) randomized controlled trial program.

Main Methods:

  • A systematic review of published observational studies assessing liraglutide's effectiveness in Indian T2DM patients.
  • Comparison of findings from ten retrieved Indian studies with data from the liraglutide RCT program (LEAD trials).

Main Results:

  • Liraglutide therapy in Indian T2DM patients resulted in significant HbA1c reductions (up to 2.54% at 52 weeks) and substantial weight loss (mean 7.4 kg at 52 weeks).
  • Indian subjects experienced greater HbA1c reduction and weight loss compared to participants in the LEAD trials.
  • Gastrointestinal events were the most frequently reported adverse events, consistent across Indian studies and the LEAD program.

Conclusions:

  • Liraglutide demonstrates superior real-world effectiveness in improving glycemic control and promoting weight loss among Indian T2DM patients compared to Western populations in RCTs.
  • The safety profile of liraglutide in India appears comparable to that observed in global clinical trials.
  • Further real-world studies are warranted to confirm these findings and optimize liraglutide use in diverse patient groups.