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Flow-sorting and Exome Sequencing of the Reed-Sternberg Cells of Classical Hodgkin Lymphoma
Published on: June 10, 2017
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Primary gastrointestinal diffuse large B-cell lymphoma: A prospective study from South India
Babu Suresh1, Vikas Asati1, K C Lakshmaiah1
1Department of Medical Oncology, Kidwai Cancer Institute, Bengaluru, Karnataka, India.
South Asian Journal of Cancer
|February 16, 2019
Summary
Primary gastrointestinal lymphoma (PGIL) most commonly affects the stomach. Localized disease and complete response to chemotherapy improve survival, but rituximab cost hinders cure for diffuse large B-cell lymphoma (DLBCL).
Area of Science:
- Oncology
- Gastroenterology
- Hematology
Background:
- Gastrointestinal tract (GIT) is a frequent extranodal site for non-Hodgkin's lymphoma (NHL), accounting for 10%-15% of all NHL cases.
- Primary GIT diffuse large B-cell lymphoma (PGIL) is a specific subtype requiring dedicated epidemiological and clinical evaluation.
Purpose of the Study:
- To evaluate the epidemiological and clinicopathological characteristics of PGIL.
- To assess the treatment outcomes for patients with PGIL.
Main Methods:
- Prospective study of newly diagnosed PGIL patients with DLBCL histology.
- Utilized the Lugano staging system for disease classification.
- Treatment involved prephase therapy followed by CHOP-based chemotherapy, with or without rituximab.
Main Results:
- 21 PGIL patients were diagnosed; median age 46 years, male:female ratio 2:1.
- Stomach was the most common site (52.4%), followed by the colon (23.8%). Abdominal pain was the most frequent symptom.
- Stage IV disease had significantly lower median survival (6.23 months) than localized disease (23.4 months). Patients not achieving complete response (CR) had a 15.5 times higher risk of death.
Conclusions:
- The stomach is the predominant site for PGIL.
- Localized disease and achieving CR after first-line chemotherapy are linked to better survival outcomes.
- The high cost of rituximab presents a barrier to achieving a cure in these patients.
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